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1:

The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.

Wood AM, Simmonds MJ, Bayley DL, Newby PR, Gough SC, Stockley RA.

Respir Res. 2008 Jul 11;9:52.

PMID: 18620570 [PubMed - indexed for MEDLINE]

2:

IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency.

Demeo DL, Campbell EJ, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Silverman EK.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):114-20. Epub 2007 Aug 9.

PMID: 17690329 [PubMed - indexed for MEDLINE]

3:

Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases.

Silverman EK, Mosley JD, Rao DC, Palmer LJ, Province MA, Elston RC, Weiss ST, Campbell EJ.

Hum Hered. 2001;52(4):223-32.

PMID: 11713419 [PubMed - indexed for MEDLINE]

4:

A polymorphism of the alpha1-antitrypsin gene represents a risk factor for liver disease.

Chappell S, Hadzic N, Stockley R, Guetta-Baranes T, Morgan K, Kalsheker N.

Hepatology. 2008 Jan;47(1):127-32.

PMID: 17972336 [PubMed - indexed for MEDLINE]

5:

Longitudinal decline of diffusing capacity of the lung for carbon monoxide in community subjects with the PiMZ alpha1-antitrypsin phenotype.

Silva GE, Guerra S, Keim S, Barbee RA, Sherrill DL.

Chest. 2008 May;133(5):1095-100. Epub 2008 Feb 8.

PMID: 18263681 [PubMed - indexed for MEDLINE]

6:

Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.

Hersh CP, Demeo DL, Lange C, Litonjua AA, Reilly JJ, Kwiatkowski D, Laird N, Sylvia JS, Sparrow D, Speizer FE, Weiss ST, Silverman EK.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):71-8. Epub 2005 Apr 7.

PMID: 15817713 [PubMed - indexed for MEDLINE]

7:

[PI*S and PI*Z alpha 1-antitrypsin deficiency: estimated prevalence and number of deficient subjects in Spain]

Blanco I, Fernández-Bustillo E, de Serres FJ, Alkassam D, Rodríguez Menéndez C.

Med Clin (Barc). 2004 Dec 4;123(20):761-5. Spanish.

PMID: 15607066 [PubMed - indexed for MEDLINE]

8:

A longitudinal study of alpha1-antitrypsin phenotypes and decline in FEV1 in a community population.

Silva GE, Sherrill DL, Guerra S, Barbee RA.

Chest. 2003 May;123(5):1435-40.

PMID: 12740258 [PubMed - indexed for MEDLINE]

9:

Alpha-1 antitrypsin Null mutations and severity of emphysema.

Fregonese L, Stolk J, Frants RR, Veldhuisen B.

Respir Med. 2008 Jun;102(6):876-84. Epub 2008 Mar 18.

PMID: 18353624 [PubMed - indexed for MEDLINE]

10:

Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema.

Ferrarotti I, Zorzetto M, Beccaria M, Gilè LS, Porta R, Ambrosino N, Pignatti PF, Cerveri I, Pozzi E, Luisetti M.

Eur Respir J. 2003 Mar;21(3):444-9.

PMID: 12661999 [PubMed - indexed for MEDLINE]

11:

Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population.

Dahl M, Tybjaerg-Hansen A, Lange P, Vestbo J, Nordestgaard BG.

Ann Intern Med. 2002 Feb 19;136(4):270-9. Summary for patients in: Ann Intern Med. 2002 Feb 19;136(4):I35.

PMID: 11848724 [PubMed - indexed for MEDLINE]

12:

[The variability of clinical presentation of chronic obstructive pulmonary disease in patients with hereditary alpha-1 antitrypsin deficiency]

Kuca P, Kamiński D, Campbell E, Kołakowski J, Goljan-Geremek A, Puścińska E, Bieleń P, Nowiński A, Wojda E, Hawryłkiewicz I, Sliwiński P, Górecka D.

Pneumonol Alergol Pol. 2004;72(9-10):420-3. Polish.

PMID: 16021998 [PubMed - indexed for MEDLINE]

13:

Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers.

Tanaka G, Sandford AJ, Burkett K, Connett JE, Anthonisen NR, Paré PD, He JQ.

Eur Respir J. 2007 Jan;29(1):34-41. Epub 2006 Sep 13.

PMID: 16971410 [PubMed - indexed for MEDLINE]

14:

The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.

Zhu G, Warren L, Aponte J, Gulsvik A, Bakke P, Anderson WH, Lomas DA, Silverman EK, Pillai SG; International COPD Genetics Network (ICGN) Investigators.

Am J Respir Crit Care Med. 2007 Jul 15;176(2):167-73. Epub 2007 Apr 19.

PMID: 17446335 [PubMed - indexed for MEDLINE]

15:

Development of a novel microarray methodology for the study of SNPs in the promoter region of the TNF-alpha gene: their association with obstructive pulmonary disease in Greek patients.

Papatheodorou A, Latsi P, Vrettou C, Dimakou A, Chroneou A, Makrythanasis P, Kaliakatsos M, Orfanidou D, Roussos C, Kanavakis E, Tzetis M.

Clin Biochem. 2007 Aug;40(12):843-50. Epub 2007 Apr 19.

PMID: 17509552 [PubMed - indexed for MEDLINE]

16:

Alpha-antitrypsin genotypes in Korean patients with chronic obstructive pulmonary disease.

Kim CH, Yim JJ, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS.

Respirology. 2005 Mar;10(2):223-8.

PMID: 15823189 [PubMed - indexed for MEDLINE]

17:

Familial risks for chronic obstructive pulmonary disease among siblings based on hospitalisations in Sweden.

Hemminki K, Li X, Sundquist K, Sundquist J.

J Epidemiol Community Health. 2008 May;62(5):398-401.

PMID: 18413451 [PubMed - indexed for MEDLINE]

18:

Genetic association analysis of functional impairment in chronic obstructive pulmonary disease.

Hersh CP, Demeo DL, Lazarus R, Celedón JC, Raby BA, Benditt JO, Criner G, Make B, Martinez FJ, Scanlon PD, Sciurba FC, Utz JP, Reilly JJ, Silverman EK.

Am J Respir Crit Care Med. 2006 May 1;173(9):977-84. Epub 2006 Feb 2.

PMID: 16456143 [PubMed - indexed for MEDLINE]

19:

Tumor necrosis factor gene polymorphisms in Turkish patients with sarcoidosis.

Seyhan EC, Cetinkaya E, Altin S, Gunluoglu Z, Demir A, Koksal V, Issever H.

Intern Med. 2008;47(9):833-8. Epub 2008 May 1.

PMID: 18451575 [PubMed - indexed for MEDLINE]

20:

Alpha one antitrypsin deficiency: from gene to treatment.

Wood AM, Stockley RA.

Respiration. 2007;74(5):481-92. Review.

PMID: 17671403 [PubMed - indexed for MEDLINE]

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