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1:

The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model.

García-Suárez Mdel M, Flórez N, Astudillo A, Vázquez F, Villaverde R, Fabrizio K, Pirofski LA, Méndez FJ.

Respir Res. 2007 Jan 26;8:3.

PMID: 17257395 [PubMed - indexed for MEDLINE]

2:

Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia.

Rubins JB, Charboneau D, Paton JC, Mitchell TJ, Andrew PW, Janoff EN.

J Clin Invest. 1995 Jan;95(1):142-50.

PMID: 7814608 [PubMed - indexed for MEDLINE]

3:

Protection against pneumococcal pneumonia in mice by monoclonal antibodies to pneumolysin.

García-Suárez Mdel M, Cima-Cabal MD, Flórez N, García P, Cernuda-Cernuda R, Astudillo A, Vázquez F, De los Toyos JR, Méndez FJ.

Infect Immun. 2004 Aug;72(8):4534-40.

PMID: 15271913 [PubMed - indexed for MEDLINE]

4:

Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice.

Marks M, Burns T, Abadi M, Seyoum B, Thornton J, Tuomanen E, Pirofski LA.

Infect Immun. 2007 Apr;75(4):1586-97. Epub 2007 Feb 12.

PMID: 17296760 [PubMed - indexed for MEDLINE]

5:

Roles of interleukin-6 and macrophage inflammatory protein-2 in pneumolysin-induced lung inflammation in mice.

Rijneveld AW, van den Dobbelsteen GP, Florquin S, Standiford TJ, Speelman P, van Alphen L, van der Poll T.

J Infect Dis. 2002 Jan 1;185(1):123-6. Epub 2001 Nov 30.

PMID: 11756992 [PubMed - indexed for MEDLINE]

6:

Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space.

Maus UA, Srivastava M, Paton JC, Mack M, Everhart MB, Blackwell TS, Christman JW, Schlöndorff D, Seeger W, Lohmeyer J.

J Immunol. 2004 Jul 15;173(2):1307-12.

PMID: 15240724 [PubMed - indexed for MEDLINE]

7:

Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci.

Dessing MC, Florquin S, Paton JC, van der Poll T.

Cell Microbiol. 2008 Jan;10(1):237-46. Epub 2007 Aug 17.

PMID: 17711480 [PubMed - indexed for MEDLINE]

8:

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.

Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MK, Dockrell DH.

J Immunol. 2006 Nov 1;177(9):6480-8.

PMID: 17056580 [PubMed - indexed for MEDLINE]

9:

Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.

Ogunniyi AD, LeMessurier KS, Graham RM, Watt JM, Briles DE, Stroeher UH, Paton JC.

Infect Immun. 2007 Apr;75(4):1843-51. Epub 2007 Jan 29.

PMID: 17261599 [PubMed - indexed for MEDLINE]

10:

Role of platelet-activating factor in pneumolysin-induced acute lung injury.

Witzenrath M, Gutbier B, Owen JS, Schmeck B, Mitchell TJ, Mayer K, Thomas MJ, Ishii S, Rosseau S, Suttorp N, Schütte H.

Crit Care Med. 2007 Jul;35(7):1756-62.

PMID: 17522574 [PubMed - indexed for MEDLINE]

11:

Cirrhosis-induced defects in innate pulmonary defenses against Streptococcus pneumoniae.

Propst-Graham KL, Preheim LC, Vander Top EA, Snitily MU, Gentry-Nielsen MJ.

BMC Microbiol. 2007 Oct 23;7:94.

PMID: 17956621 [PubMed - indexed for MEDLINE]

12:

Streptococcus pneumoniae strain-dependent lung inflammatory responses in a murine model of pneumococcal pneumonia.

Mohler J, Azoulay-Dupuis E, Amory-Rivier C, Mazoit JX, Bédos JP, Rieux V, Moine P.

Intensive Care Med. 2003 May;29(5):808-16. Epub 2003 Mar 29.

PMID: 12665994 [PubMed - indexed for MEDLINE]

13:

Pneumolysin: a multifunctional pneumococcal virulence factor.

Rubins JB, Janoff EN.

J Lab Clin Med. 1998 Jan;131(1):21-7. Review.

PMID: 9452123 [PubMed - indexed for MEDLINE]

14:

Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice.

Wang E, Simard M, Ouellet N, Bergeron Y, Beauchamp D, Bergeron MG.

Infect Immun. 2002 Aug;70(8):4226-38.

PMID: 12117931 [PubMed - indexed for MEDLINE]

15:

Nonspecificity of assaying for IgG antibody to pneumolysin in circulating immune complexes as a means to diagnose pneumococcal pneumonia.

Musher DM, Mediwala R, Phan HM, Chen G, Baughn RE.

Clin Infect Dis. 2001 Feb 15;32(4):534-8. Epub 2001 Feb 9.

PMID: 11181114 [PubMed - indexed for MEDLINE]

16:

Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

Jounblat R, Kadioglu A, Mitchell TJ, Andrew PW.

Infect Immun. 2003 Apr;71(4):1813-9. Erratum in: Infect Immun. 2003 Dec;71(12):7239.

PMID: 12654795 [PubMed - indexed for MEDLINE]

17:

Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.

Maus UA, Backi M, Winter C, Srivastava M, Schwarz MK, Rückle T, Paton JC, Briles D, Mack M, Welte T, Maus R, Bohle RM, Seeger W, Rommel C, Hirsch E, Lohmeyer J, Preissner KT.

Am J Respir Crit Care Med. 2007 May 1;175(9):958-66. Epub 2007 Feb 22.

PMID: 17322108 [PubMed - indexed for MEDLINE]

18:

Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease.

Srivastava A, Casey H, Johnson N, Levy O, Malley R.

Infect Immun. 2007 Jan;75(1):342-9. Epub 2006 Nov 13.

PMID: 17101667 [PubMed - indexed for MEDLINE]

19:

Immunodetection of pneumolysin in human urine by ELISA.

Cima-Cabal MD, Méndez FJ, Vázquez F, Aranaz C, Rodríguez-Alvarez J, García-García JM, Fleites A, Martínez González-Río J, Molinos L, de Miguel D, de los Toyos JR.

J Microbiol Methods. 2003 Jul;54(1):47-55.

PMID: 12732421 [PubMed - indexed for MEDLINE]

20:

Modulation of the inflammatory response to Streptococcus pneumoniae in a model of acute lung tissue infection.

Xu F, Droemann D, Rupp J, Shen H, Wu X, Goldmann T, Hippenstiel S, Zabel P, Dalhoff K.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):522-9. Epub 2008 May 15.

PMID: 18483419 [PubMed - indexed for MEDLINE]

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