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Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.

Failla M, Genovese T, Mazzon E, Gili E, Muià C, Sortino M, Crimi N, Caputi AP, Cuzzocrea S, Vancheri C.

Respir Res. 2006 Nov 21;7:137.

PMID: 17118201 [PubMed - indexed for MEDLINE]

Protective effect of orally administered carnosine on bleomycin-induced lung injury.

Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C.

Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1095-104. Epub 2007 Jan 12.

PMID: 17220373 [PubMed - indexed for MEDLINE]

Cysteinyl-leukotriene 1 receptor antagonist attenuates bleomycin-induced pulmonary fibrosis in mice.

Izumo T, Kondo M, Nagai A.

Life Sci. 2007 Apr 24;80(20):1882-6. Epub 2007 Mar 12.

PMID: 17397875 [PubMed - indexed for MEDLINE]

Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury.

Genovese T, Cuzzocrea S, Di Paola R, Failla M, Mazzon E, Sortino MA, Frasca G, Gili E, Crimi N, Caputi AP, Vancheri C.

Respir Res. 2005 Jun 14;6:58.

PMID: 15955252 [PubMed - indexed for MEDLINE]

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Melatonin limits lung injury in bleomycin treated mice.

Genovese T, Di Paola R, Mazzon E, Muià C, Caputi AP, Cuzzocrea S.

J Pineal Res. 2005 Sep;39(2):105-12.

PMID: 16098086 [PubMed - indexed for MEDLINE]

Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation.

Cuzzocrea S, Ronchetti S, Genovese T, Mazzon E, Agostini M, Di Paola R, Esposito E, Muià C, Nocentini G, Riccardi C.

FASEB J. 2007 Jan;21(1):117-29. Epub 2006 Nov 29.

PMID: 17135359 [PubMed - indexed for MEDLINE]

Glycogen synthase kinase-3beta inhibition attenuates the development of bleomycin-induced lung injury.

Cuzzocrea S, Genovese T, Mazzon E, Esposito E, Muià C, Abdelrahman M, Di Paola R, Bramanti P, Thiemermann C.

Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):619-30.

PMID: 17880775 [PubMed - indexed for MEDLINE]

ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR alpha IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY.

Genovese T, Mazzon E, Di Paola R, Muià C, Crisafulli C, Caputi AP, Cuzzocrea S.

Shock. 2005 Dec;24(6):547-55.

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Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.

Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H.

Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65. Epub 2005 Sep 9.

PMID: 16155090 [PubMed - indexed for MEDLINE]

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Bleomycin injury of the lung in a mast-cell-deficient model.

O'Brien-Ladner AR, Wesselius LJ, Stechschulte DJ.

Agents Actions. 1993 May;39(1-2):20-4.

PMID: 7506864 [PubMed - indexed for MEDLINE]

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E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis.

Horikawa M, Fujimoto M, Hasegawa M, Matsushita T, Hamaguchi Y, Kawasuji A, Matsushita Y, Fujita T, Ogawa F, Takehara K, Steeber DA, Sato S.

Am J Pathol. 2006 Sep;169(3):740-9.

PMID: 16936251 [PubMed - indexed for MEDLINE]

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Interleukin-1 mediates thermal injury-induced lung damage through C-Jun NH2-terminal kinase signaling.

Chen LW, Chang WJ, Wang JS, Hsu CM.

Crit Care Med. 2007 Apr;35(4):1113-22.

PMID: 17334237 [PubMed - indexed for MEDLINE]

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Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.

Genovese T, Mazzon E, Di Paola R, Muià C, Threadgill MD, Caputi AP, Thiemermann C, Cuzzocrea S.

J Pharmacol Exp Ther. 2005 May;313(2):529-38. Epub 2005 Jan 11.

PMID: 15644425 [PubMed - indexed for MEDLINE]

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[The pivotal role of CXCR3 in the pathogenesis of bleomycin-induced pulmonary fibrosis]

Gao JM, Lu B.

Zhonghua Jie He He Hu Xi Za Zhi. 2005 Jan;28(1):28-32. Chinese.

PMID: 15774188 [PubMed - indexed for MEDLINE]

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Zileuton reduces respiratory illness and lung inflammation, during respiratory syncytial virus infection, in mice.

Welliver RC 2nd, Hintz KH, Glori M, Welliver RC Sr.

J Infect Dis. 2003 Jun 1;187(11):1773-9. Epub 2003 May 15.

PMID: 12751035 [PubMed - indexed for MEDLINE]

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Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury.

Volmer JB, Thompson LF, Blackburn MR.

J Immunol. 2006 Apr 1;176(7):4449-58.

PMID: 16547283 [PubMed - indexed for MEDLINE]

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Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced lung fibrosis.

Fujimoto H, Gabazza EC, Taguchi O, Nishii Y, Nakahara H, Bruno NE, D'Alessandro-Gabazza CN, Kasper M, Yano Y, Nagashima M, Morser J, Broze GJ, Suzuki K, Adachi Y.

Am J Pathol. 2006 Apr;168(4):1086-96.

PMID: 16565485 [PubMed - indexed for MEDLINE]

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Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice.

Tabata C, Tabata R, Kadokawa Y, Hisamori S, Takahashi M, Mishima M, Nakano T, Kubo H.

J Immunol. 2007 Jul 1;179(1):708-14.

PMID: 17579094 [PubMed - indexed for MEDLINE]

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Therapeutic treatments of phosgene-induced lung injury.

Sciuto AM, Hurt HH.

Inhal Toxicol. 2004 Jul;16(8):565-80. Review.

PMID: 15204747 [PubMed - indexed for MEDLINE]

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Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.

Lawson WE, Polosukhin VV, Stathopoulos GT, Zoia O, Han W, Lane KB, Li B, Donnelly EF, Holburn GE, Lewis KG, Collins RD, Hull WM, Glasser SW, Whitsett JA, Blackwell TS.

Am J Pathol. 2005 Nov;167(5):1267-77.

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