Purified capsular polysaccharide of Cryptococcus neoformans induces interleukin-10 secretion by human monocytes.
Vecchiarelli A, Retini C, Monari C, Tascini C, Bistoni F, Kozel TR.
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes. Endogenous IL-10 was involved in regulating tumor necrosis factor alpha and IL-1beta secretion by human monocytes in response to encapsulated C. neoformans strains. Our results suggest a new immunosuppressive effect exerted by glucuronoxylomannan through the induction of IL-10, a potent downregulator of proinflammatory cytokines.
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PMID: 8698522 [PubMed - indexed for MEDLINE]PMCID: PMC174153