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1: Chest. 1987 Jun;91(6 Suppl):189S-191S.
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Bronchial hyporesponsiveness.

Macklem PT.

It is argued that the dose-response curve for asthmatic patients is of a form that would be expected from the in vitro active force length relationship of bronchial smooth muscle if shortening at maximal isometric tension is quasi-isotonic. If this is the case, it may be more important to attempt to explain normal bronchial hyporesponsiveness, in particular whether bronchoconstriction is quasi-isotonic. In vivo response to inhalation depends on change in length of bronchial smooth muscle cells. Further studies should focus on factors influencing change in length rather than change in force.

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PMID: 3581958 [PubMed - indexed for MEDLINE]