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1: Respir Res. 2001;2(2):71-9. Epub 2001 Mar 8.
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Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease.

Greenfeder S, Umland SP, Cuss FM, Chapman RW, Egan RW.

Allergy Department, Schering Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA. scott.greenfeder@spcorp.com

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans.

Publication Types:
PMID: 11686868 [PubMed - indexed for MEDLINE]

PMCID: PMC59571