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Chitinase expression in three different strains of rats infected with C. neoformans |
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| TH bias** |
BAL |
LUNG |
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| PBS |
INFECTED |
PBS |
INFECTED |
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|
|
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| Fischer |
1 [3,11] |
1.8 ± 0.4 |
11.9 ± 2.6* |
2.1 ± 0.3 |
10.6 ± 1.3* |
| Sprague Dawley |
Outbred, Non-biased [12,20] |
1.8 ± 0.5 |
15.2 ± 4.4* |
0.7 ± .01 |
6.4 ± 1.0* |
| Brown Norway |
2 [12,20] |
1.9 ± 0.5 |
6.6 ± 3.9* |
1.4 ± .03 |
5.1 ± 1.7* |
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Chitinase activity (units × 10-3/ml) in different rat strains following experimental pulmonary cryptococcal infection. Values represent means ± 1 SD. For all experiments 4–5 animals were used per group and measurements done at 2 weeks. * P < 0.05 for comparison between infected tissues and PBS-inoculated controls. **TH bias of rat strain reflects tendency to develop TH1 (cellular) versus TH2 (humoral/allergic) inflammation in response to infection or antigen challenge. | |||||
Vicencio et al. Respiratory Research 2008 9:40 doi:10.1186/1465-9921-9-40 |
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