Figure 3.

HMGB1 release from A549 cells induced by L. pneumophila infection. A549 cells were infected with L. pneumophila virulent AA100jm and avirulent dotO mutant strains. After incubation, HMGB1 levels in the supernatant showed an MOI dose-response relationship 2 days after infection. Symbols : ▫, virulent strain AA100jm; ▪, avirulent strain dotO mutant. Data are mean ± SD of three wells. * P < 0.05.