Table 3

Weighted GSMA for bronchial hyper-responsiveness (989 pedigrees, n = 4,294)






PROBABILITY






BIN(a)
GENETIC LOCUS(b)
DISTANCE (cM)(c)
PHYSICAL POSITION (KB)(d)
SUMMED RANK (SR)
p(SR)
p(OR)

14
2p16.2-p12
76.34–101.56
54063–79617
532.855
0.02751
0.22094
15
2p12-q22.1
101.56–128.41
79617–119705
576.585
0.00574*
0.14743
16
2q22.1-q23.3
128.41–154.48
119705–151529
518.593
0.04085
0.08859
41
5q23.2-q34
131.48–164.19
123774–162087
551.701
0.01511
0.09586
44
6p22.3-p21.1
32.62–65.14
16854–43207
571.381
0.00716*
0.04861
50
7p21.1-p14.1
29.28–59.93
19430–40230
523.367
0.03597
0.24658
51
7p14.1-q21.11
59.93–91.67
40230–81002
518.746
0.04070
0.19114
52
7q21.11-q31.1
91.67–122.48
81002–109766
461.380
0.13926
0.02065
58
8q13.1-q22
82.84–110.20
67744–99237
468.188
0.12312
0.04443
76
11q13.3-q22.3
72.82–98.98
70185–103732
465.589
0.12913
0.01652
78
11q24.1-qter
123.00–147.77
122977-qter
579.520
0.00505*
0.46485
86
13q13.2-q22.2
26.87–58.54
33636–74875
472.999
0.11255
0.03312
111
19q12-q13.33
52.59–75.41
35843–54589
460.759
0.14078
0.01070
115
20p11-q13.13
47.52–72.27
21259–46747
476.308
0.10563
0.03503
116
20q13.13-qter
72.27–101.22
46747-qter
467.593
0.12448
0.02343

Chromosomal regions with a p(SR) or p(OR) < 0.05 are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage [5].

Denham et al. Respiratory Research 2008 9:38   doi:10.1186/1465-9921-9-38