|
Weighted GSMA for Asthma (1,267 pedigrees, n = 5,832) |
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| PROBABILITY |
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|
|
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| BIN(a) |
GENETIC LOCUS(b) |
DISTANCE (cM)(c) |
PHYSICAL POSITION (KB)(d) |
SUMMED RANK (SR) |
p(SR) |
p(OR) |
|
|
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| 1 |
1pter-p36.23 |
0.00–20.61 |
pter-9332 |
376.576 |
0.68121 |
0.03775 |
| 5 |
1p31.1-p13.3 |
113.69–142.24 |
82867–110103 |
346.834 |
0.78259 |
0.00718* |
| 8 |
1q31.1-q32 |
201.58–231.11 |
185232–210150 |
347.872 |
0.77937 |
0.02791 |
| 15 |
2p12-q22.1 |
101.56–128.41 |
79617–119705 |
341.174 |
0.79974 |
0.00694* |
| 18 |
2q31.1-q34 |
177.53–206.74 |
172805–212021 |
317.985 |
0.86170 |
0.03548 |
| 20 |
2q35-qter |
233.62–269.07 |
230618-qter |
316.169 |
0.86603 |
0.00908 |
| 24 |
3p14.1-q12.3 |
88.60–117.76 |
64182–103187 |
612.921 |
0.02348 |
0.80059 |
| 31 |
4p14-q13.3 |
51.60–78.97 |
38279–72275 |
343.939 |
0.79152 |
0.00714* |
| 34 |
4q28.3-q32.1 |
134.74–159.30 |
137492–160828 |
346.992 |
0.78212 |
0.01609 |
| 43 |
6pter-p22.3 |
0.00–32.62 |
pter-16854 |
383.747 |
0.65433 |
0.03220 |
| 44 |
6p22.3-p21.1 |
32.62–65.14 |
16854–43207 |
592.740 |
0.03905 |
0.72593 |
| 50 |
7p21.1-p14.1 |
29.28–59.93 |
19430–40230 |
317.779 |
0.86218 |
0.01583 |
| 53 |
7q31.1-q34 |
122.48–148.11 |
75216–138638 |
381.650 |
0.66230 |
0.03107 |
| 54 |
7q34-qter |
148.11–181.97 |
138638-qter |
313.741 |
0.87152 |
0.00536* |
| 55 |
8pter-p22 |
0.00–27.40 |
pter-13111 |
376.368 |
0.68196 |
0.01899 |
| 59 |
8q22-q24.21 |
110.2–137.92 |
99237–127416 |
365.804 |
0.71999 |
0.02820 |
| 60 |
8q24.21-qter |
137.92–167.90 |
127416-qter |
373.141 |
0.69378 |
0.02636 |
| 62 |
9p22.3-p21.1 |
27.32–53.60 |
14264–29850 |
349.926 |
0.77291 |
0.03321 |
| 68 |
10p14-q11.21 |
29.15–62.23 |
10591–36230 |
635.659 |
0.01229 |
0.79026 |
| 75 |
11p12-q13.3 |
47.06–72.82 |
36450–70234 |
353.473 |
0.76155 |
0.02578 |
| 79 |
12pter-p12.1 |
0.00–24.45 |
pter-11686 |
299.278 |
0.90180 |
0.00570* |
| 80 |
12p12.1-p11.21 |
24.45–53.28 |
11686–32879 |
292.228 |
0.91466 |
0.00766* |
| 84 |
12q24.31-qter |
139.61–170.60 |
120806-qter |
607.388 |
0.02714 |
0.65821 |
| 87 |
13q22.2-q33.1 |
58.54–85.41 |
74875–102346 |
354.469 |
0.75831 |
0.04007 |
| 89 |
14pter-q13.1 |
0.00–40.11 |
pter- 33529 |
362.366 |
0.73182 |
0.03622 |
| 92 |
14q32.12-qter |
105.00-138.18 |
90647-qter |
305.539 |
0.88932 |
0.00423* |
| 101 |
17pter-p12 |
0.00–25.14 |
pter-11325 |
312.768 |
0.87374 |
0.00213* |
| 105 |
18pter-p11 |
0.00–24.08 |
pter- 7462 |
377.842 |
0.67650 |
0.04965 |
| 113 |
20pter-p12.3 |
0.00–21.15 |
pter-7608 |
339.111 |
0.80587 |
0.00524* |
| 114 |
20p12.3-p11 |
21.15–47.52 |
7608–21259 |
282.935 |
0.92982 |
0.01324 |
|
Chromosomal regions with a p(SR) or p(OR) < 0.05 are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage [5]. | ||||||
Denham et al. Respiratory Research 2008 9:38 doi:10.1186/1465-9921-9-38 |
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