Table 1

Characteristics of genome-wide linkage studies included in the GSMA


NUMBER OF.(b)









COHORT (REF.)
 PHENOTYPES(a)
 PED. (AFF/IND.)
 MKS.
 WF.
 MKR MAP (SP.)(c)
 STUDY TYPE(d)
 ANALYSIS PROGRAM
 INCLUDED IN GSMA
Australian [9]
 B: Slope (-,0–12 μmol meth.)
 80 (25/364)
 253
 142.267
 - (10 cM)
 Nonpar.two.
 -
 B: 23 p-values < 0.05

I: Quantitative





I: 21 p-values < 0.05

S: 2 allergens





S: 19 p-values < 0.05
CSGA [33]
 A: Quest./Doc diag
 79 (200/316)
 360
 168.642
 Marshfield (10 cM)
 Nonpar. multi.
 Modified GENEHUNTER
 A: LOD scores from graphs
German [34]
 B: PD20 (Neb, < 8 mg/ml meth.)
 97 (200/415)
 333
 179.725
 Modified Genethon (10.7 cM)
 Nonpar. multi.
 GENEHUNTER, MAP-MAKER/SIBS
 B: Complete dataset
French [11]
 A: Quest./Meds.
 46 (102/210)
 254
 108.093
 – (13 cM)
 Nonpar. multi.
 GENEHUNTER, SIBPAIR
 A: 11 p-values

B: Slope (-, meth.)





B: 8 p-values

I: Quantitative





I: 8 p-values

S: 11 allergens





S: 19 p-values
Icelandic [35]
 A: Doc diag./Meds.
 175 (596/1134)
 976*
 413.280
 Decode (4 cM)
 Nonpar. multi.
 ALLEGRO
 A: LOD scores from graphs
Dutch [10, 36, 37]
 A: Algorithm
 200 (-/1159)
 366
 270.555
 Marshfield Weber v8 (10 cM)
 Nonpar.
 SOLAR, GENEHUNTER
 A: Complete dataset

B: PD20 (-, < 32 mg/ml hist.)





B: Complete dataset

I: Quantitative





I: Complete dataset

S: 16 allergens





S: Complete dataset
German [12]
 A: Doc diag.
 201 (506/867)
 364
 270.489
 Modified Genethon (10 cM)
 Nonpar. multi.
 MERLIN
 A: Complete dataset

I: Quantitative/Catagorical





I: Complete quantitative dataset

S: HDM+





S: Complete dataset
Australian [13]
 A: Quest./Meds.
 202 (169/591)
 624
 355.032
 - (7.1 cM)
 Nonpar. multi.
 MERLIN, SOLAR
 A: Complete dataset

B: PD20 (-, < 7.8 μmol hist)





B: Complete dataset

I: Quantitative





I: Complete dataset

S: 11 allergens.





S: Complete dataset
GAIN [16]
 A: Doc diag.
 364 (1014/1555)
 396*
 379.663
 Decode (-)
 Nonpar. multi.
 MERLIN
 A: LOD scores from graphs

B: PD20 (-, < 8 mg/ml meth.)





B: LOD scores from graphs

S: 7 allergens





S: LOD scores from graphs

(a) A = asthma; B = bronchial hyper-responsiveness (Neb = nebuliser, Dos = dosimeter); I = total serum IgE; S = skin prick test response; Quest = questionnaire; Doc diag = doctor diagnosis; Meds = asthma medication; Meth = methacholine; Hist = histamine; HDM = house dust mite; PD20 = provocation dose resulting in a 20% fall in FEV1. (b) Ped = total genotyped pedigrees; AFF = total genotyped asthmatic cases, Ind = total genotyped individuals; Mks = total autosomal microsatellite markers; Wt = weighting factor. (c) Sp = average marker spacing. (d) Nonpar = nonparametric; Two = two point; Multi = multipoint. (-) = not provided, *number of autosomal markers not given, total number used for weighting.

Denham et al. Respiratory Research 2008 9:38   doi:10.1186/1465-9921-9-38