|
Mean (SE) FEV1 %predicted in relation to AAT quintile classes † |
|||||||
| Quintile classes of AAT (g/l) |
|||||||
|
|
|||||||
| Q0 (<0.9) |
Q1 (≥0.9–<1.13) |
Q2 (≥1.13, <1.22) |
Q3 (≥1.22, <1.31) |
Q4 (≥1.31, <1.41) |
Q5 (≥1.41) |
ptrend from model not including Q0 |
|
|
|
|||||||
| All (n) ¶ |
152 |
952 |
832 |
932 |
764 |
817 |
|
| FEV1 (% predicted) CRP adj. |
99.8 (1.2) |
98.0 (0.5) |
98.3 (0.5) |
98.1 (0.5) |
97.6 (0.5) |
96.6 (0.5) |
0.28 |
| FEV1 (% predicted), no CRP adj. * |
100.4 (1.2) |
98.7 (0.5) |
98.7 (0.5) |
98.2 (0.5) |
97.4 (0.5) |
95.5 (0.5) |
<0.001 |
| Men (n)‡ |
79 |
627 |
511 |
460 |
351 |
256 |
|
| FEV1 (% predicted) CRP adj. |
99.0 (1.6) |
96.7 (0.6) |
97.3 (0.6) |
97.2 (0.6) |
95.8 (0.8) |
93.8 (1.0) |
0.08 |
| FEV1 (% predicted), no CRP adj. * |
99.3 (1.6) |
97.3 (0.6) |
97.6 (0.6) |
97.1 (0.7) |
95.4 (0.8) |
92.6 (0.9) |
<0.001 |
| Women (n) ¶, ‡ |
73 |
325 |
321 |
472 |
413 |
561 |
|
| FEV1 (% predicted) CRP adj. |
100.6 (1.6) |
99.4 (0.8) |
99.2(0.8) |
99.3(0.7) |
99.2 (0.7) |
98.8 (0.6) |
0.76 |
| FEV1 (% predicted), no CRP adj. * |
101.4 (1.7) |
99.9 (0.8) |
99.7(0.8) |
99.5(0.7) |
99.3 (0.7) |
97.8 (0.6) |
0.19 |
| Never/Former Smokers (n) ¶, ‡ |
130 |
811 |
721 |
754 |
541 |
537 |
|
| FEV1 (% predicted), CRP adj. |
100.4 (1.3) |
99.1 (0.5) |
99.0 (0.5) |
99.1 (0.5) |
98.4 (0.6) |
96.9 (0.7) |
0.10 |
| FEV1 (% predicted), no CRP adj.* |
100.9 (1.3) |
99.6 (0.5) |
99.3 (0.5) |
99.1 (0.5) |
98.2 (0.6) |
95.9 (0.7) |
<0.001 |
| Current Smokers (n) ¶, ‡ |
22 |
141 |
111 |
178 |
223 |
280 |
|
| FEV1 (% predicted), CRP adj. |
96.9 (2.9) |
93.6 (1.2) |
95.0 (1.3) |
93.8 (1.0) |
94.5 (0.9) |
95.6 (0.9) |
0.16 |
| FEV1 (% predicted), no CRP adj.* |
97.2 (2.9) |
94.3 (1.0) |
95.7 (1.3) |
94.3 (1.0) |
94.7 (0.9) |
94.5 (0.9) |
0.91 |
| Currents Smokers ≥15 cigs/d (n) ¶,‡ |
11 |
60 |
48 |
103 |
122 |
182 |
|
| FEV1 (% predicted), CRP adj. |
96.5 (4.3) |
88.8 (1.9) |
93.6 (2.1) |
91.2 (1.4) |
93.6 (1.3) |
95.3 (1.1) |
0.01 |
| FEV1 (% predicted), no CRP adj.* |
96.7 (4.3) |
89.7 (1.9) |
94.4 (1.1) |
91.2 (1.4) |
93.9 (1.3) |
94.4 (1.1) |
0.06 |
| Currents Smokers <15 cigs/d (n) ¶,‡ |
11 |
81 |
63 |
75 |
101 |
98 |
|
| FEV1 (% predicted), CRP adj. |
99.6 (3.9) |
98.3 (1.5) |
96.9 (1.7) |
96.6 (1.5) |
95.8 (1.3) |
94.9 (1.5) |
0.21 |
| FEV1 (% predicted), no CRP adj.* |
99.9 (3.9) |
98.9 (1.5) |
97.6 (1.4) |
97.2 (1.5) |
95.9 (1.3) |
93.5 (1.4) |
0.02 |
|
† adjusted for gender, smoking status (never, former, current), years since quitting in former smokers, cigarettes/day in current smokers, passive smoking in never smokers, BMI, systolic blood pressure, alcohol consumption, study area, menopausal status in women, intake of female hormones in women, CRP, CRP2 (models with CRP adjustment); * adjusted for all covariates but CRP; ¶women in perimenopausal status (n = 35) and missing/unclear status and hormonal intake (n = 120) were excluded from the analysis; ‡ P-values for interactions: In All: AAT*gender: p = 0.02(CRP adj); p = 0.007(no CRP adj.); In women: AAT*menopausal status: 0.01 (CRP adj.); 0.008 no CRP adj.); AAT*intake female hormones: p > 0.80, irrespective of menopausal status; AAT*smoking (heavy current smoking vs. all others): all men: p = 0.02 (CRP adj.); p = 0.03 (no CRP adj.); all women: p = 0.11 (CRP adj.); p = 0.11 (no CRP adj.); postmenopausal women: p = 0.08 (CRP adj.); p = 0.07 (no CRP adj.); premenopausal women: p = 0.59 (CRP adj.); p = 0.58 (no CRP adj.) | |||||||
Senn et al. Respiratory Research 2008 9:35 doi:10.1186/1465-9921-9-35 |
|||||||