|
Adjusted* mean AAT serum levels by age, gender, anthropometrics, blood pressure, crp, and lifestyle variables (n = 5187) |
||||
| Number of subjects |
AAT (SE) (g/L), no CRP adjustment |
AAT (SE) (g/L), CRP adjustment |
||
|
|
||||
| Gender |
Men |
2518 |
1.203 (0.004) |
1.215 (0.004) |
| Women |
2669 |
1.305 (0.004) |
1.293 (0.004) |
|
| p < 0.001 |
p < 0.001 |
|||
| Age |
Quartiles (years): |
|||
| Men |
<43 |
630 |
1.194 (0.007) |
1.195 (0.007) |
| <53 |
629 |
1.200 (0.007) |
1.205 (0.006) |
|
| <61 |
630 |
1.208 (0.007) |
1.208 (0.006) |
|
| <73 |
629 |
1.239 (0.007) |
1.233 (0.007) |
|
| p trend < 0.001 |
p trend = 0.001 |
|||
| Premenopausal women¶,† |
<38 |
202 |
1.314 (0.013) |
1.312 (0.012) |
| <43 |
201 |
1.284 (0.013) |
1.284 (0.012) |
|
| <50 |
202 |
1.278 (0.013) |
1.281 (0.012) |
|
| <55 |
201 |
1.227 (0.013) |
1.227 (0.012) |
|
| p trend < 0.001 |
p trend < 0.001 |
|||
| Postmenopausal women¶,† |
<55 |
212 |
1.221 (0.014) |
1.221 (0.013) |
| <61 |
212 |
1.255 (0.013) |
1.261 (0.012) |
|
| <67 |
212 |
1.281 (0.013) |
1.276 (0.013) |
|
| <73 |
212 |
1.275 (0.013) |
1.273 (0.013) |
|
| p trend 0.05 |
p trend 0.07 |
|||
| BMI |
Quartiles (kg/m2): |
|||
| <22.79 |
1338 |
1.284 (0.005) |
1.306 (0.005) |
|
| <25.38 |
1349 |
1.250 (0.005) |
1.257 (0.005) |
|
| <28.36 |
1287 |
1.241 (0.005) |
1.237 (0.005) |
|
| ≥28.36 |
1213 |
1.247 (0.005) |
1.218 (0.005) |
|
| p trend = 0.003 |
p trend < 0.001 |
|||
| Systolic blood pressure |
Quartiles (mmHg): |
|||
| <114 |
1342 |
1.240 (0.006) |
1.244 (0.005) |
|
| <126 |
1279 |
1.252 (0.005) |
1.254 (0.005) |
|
| <139 |
1304 |
1.260 (0.005) |
1.259 (0.005) |
|
| ≥139 |
1262 |
1.272 (0.006) |
1.266 (0.005) |
|
| p trend < 0.001 |
p trend 0.002 |
|||
| Tobacco exposure‡ |
Never smokers/ETS- |
2121 |
1.236 (0.005) |
1.238 (0.004) |
| Never smokers/ETS+ |
388 |
1.260 (0.010) |
1.269 (0.009) |
|
| Former smokers/ETS- |
1188 |
1.238 (0.006) |
1.240 (0.005) |
|
| Former smokers/ETS+ |
312 |
1.249 (0.011) |
1.249 (0.010) |
|
| Current smokers, <15 cig/d) |
515 |
1.284 (0.008) |
1.285 (0.008) |
|
| Current smokers, ≥15 cig/d) |
662 |
1.328 (0.009) |
1.314 (0.008) |
|
| p trend < 0.0001 |
p trend < 0.0001 |
|||
| Alcohol intake |
<1 drink per day |
4069 |
1.261 (0.003) |
1.262 (0.003) |
| ≥1 drink per day |
1118 |
1.235 (0.006) |
1.234 (0.007) |
|
| p < 0.001 |
p < 0.001 |
|||
| CRP |
Quartiles (mg/l): |
|||
| <0.6 |
1506 |
1.182 |
- |
|
| <1.1 |
1202 |
1.227 |
- |
|
| <2.2 |
1232 |
1.268 |
- |
|
| ≥ 2.2 |
1247 |
1.360 |
- |
|
| P trend < 0.00001 |
||||
|
*adjusted for age, gender, smoking status, alcohol intake, BMI, systolic blood pressure and study area ¶women taking oral contraceptives (n = 166), hormone replacement (n = 524), with perimenopausal status (n = 82), and unclear/missing hormonal status (n = 243) were excluded; †p(interaction) pre-versus postmenopausal women <0.001; ‡ n = 5186, due to 1 former smoker with missing ETS exposure; ETS = environmental tobacco exposure | ||||
Senn et al. Respiratory Research 2008 9:35 doi:10.1186/1465-9921-9-35 |
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