Table 5

Total amount [nmol/vial] of drug related compounds in human lung tissue slices

Incubation time [h]
 Parent compound
 Active compound
 Fatty acid esters
 Inactive metabolite
Beclomethasone
2
 2.19 ± 0.83
 7.88 ± 2.21
 0.90 ± 0.46
 0.38 ± 0.06
dipropionate2
 6
 0.72 ± 0.46
 7.78 ± 3.80
 0.50 ± 0.40
 1.89 ± 0.49

24
 -
 2.73 ± 2.22
 0.87 ± 0.96
 5.72 ± 1.20
Budesonide1
 2
 7.32 ± 0.99
 3.17 ± 2.00
 -

6
 8.41 ± 2.15
 5.39 ± 4.03
 -

24
 9.04 ± 1.14
 8.91 ± 5.15
 -
Ciclesonide
 2
 6.46 ± 0.92
 0.76 ± 0.2
 0.40 ± 0.20
 -

6
 8.86 ± 1.68
 2.17 ± 0.51
 1.10 ± 0.73
 -

24
 9.53 ± 1.70
 7.61 ± 1.31
 7.29 ± 3.79
 -
Fluticasone1
 2
 8.42 ± 1.26
 -
 -
propionate
 6
 8.62 ± 2.20
 -
 -

24
 9.51 ± 2.22
 -
 -

Data are presented as mean ± standard deviation (n = 9).

1Parent and active compound.

2The active compound of BDP may be overestimated as inactive 21-BMP may be included.

Nave et al. Respiratory Research 2007 8:65   doi:10.1186/1465-9921-8-65