Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma

doi:10.1186/1465-9921-8-52

Respiratory Research

Volume 8

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Houghton CM
Lawson N
Borrill ZL
Wixon CL
Yoxall S
Langley SJ
Woodcock A
Singh D

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Lawson N
Borrill ZL
Wixon CL
Yoxall S
Langley SJ
Woodcock A
Singh D
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Research

Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma

Catherine M Houghton¹^,3 , Naomi Lawson¹ , Zoe L Borrill¹^,3 , Claire L Wixon² , Sally Yoxall² , Stephen J Langley¹^{^} , Ashley Woodcock¹^,3 and Dave Singh¹^,3

¹North West Lung Research Centre, South Manchester University Hospitals Trust, Manchester, UK

²Research and Development, GlaxoSmithKline, Greenford, Middlesex, UK

³Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK

author email corresponding author email^Deceased

Respiratory Research 2007, 8:52doi:10.1186/1465-9921-8-52


Published:	14 July 2007

Abstract

Background

This study compared the effect of inhaled fluticasone propionate (FP) with the combination of salmeterol/fluticasone propionate (SFC) on lung function parameters in patients with mild asthma.

Methods

Adult patients with mild persistent asthma (≥ 80% predicted FEV₁) receiving 200–500 μg of BDP or equivalent were randomised to receive either FP 100 μg or SFC 50/100 μg twice daily from a Diskus^®inhaler for four weeks. The primary outcome was the change from baseline in airway resistance (sRaw) at 12 hrs post dose measured by whole body plethysmography. Impulse oscillometry and spirometry were also performed.

Results

A comparison of the geometric mean sRaw at 12 hrs post dose in the SFC group to the FP group gave a ratio of 0.76 (0.66 – 0.89, p < 0.001) at week 2 and 0.81 (0.71 – 0.94, p = 0.006) at week 4. Similarly, significant results in favour of SFC for oscillometry measurements of resistance and reactance were observed. FEV₁was also significantly superior at week 2 in the SFC group (mean difference 0.16L, 95% CI; 0.03 – 0.28, p = 0.015), but not at week 4 (mean difference 0.17L, 95% CI -0.01 – 0.34, p = 0.060).

Conclusion

SFC is superior to FP in reducing airway resistance in mild asthmatics with near normal FEV₁values. This study provides evidence that changes in pulmonary function in patients with mild asthma are detected more sensitively by plethysmography compared to spirometry

Trial registration number

NCT00370591.