Figure 3.

H&E staining of bleomycin-treated rat lungs with and without antisense HSP47 ODN. (A) Lungs from the saline group; 40× (B) Lungs from the Bleo group at 4 weeks following bleomycin treatment exhibit diffuse consolidation of parenchyma with loss of alveolar architecture and increased cell number; 40×. (C) Lungs from the Bleo+AS group at 4 weeks post-injection demonstrates improvement of lesions compared to the Bleo alone group; 40×. (D) Lungs from the AS alone group at 4 weeks post-injection show no significant pulmonary consolidation or fibrosis; 40×. (E) Lungs from the Bleo+S group at 4 weeks post-injection exhibit diffuse consolidation of parenchyma with loss of alveolar architecture and increased cell number; 40×.