Figure 1.

Immunohistochemistry for the detection of HSP47 in rat lungs treated with bleomycin with or without antisense HSP47 oligonucleotides (ODN). (A) A representative lung from a control rat sacrificed at 4 weeks after saline administration; 400×. (B) A representative lung from an animal in the Bleo group and sacrificed at 4 weeks; 400×. (C) A representative lung from an animal in the Bleo+AS group sacrificed at 4 weeks; 400×. (D) A representative lung from an animal in the antisense group sacrificed at 4 weeks; 400×. (E) A representative lungs from an animal in the Bleo+S group and sacrificed at 4 weeks; 400×. Arrows indicate immunopositivity cells to HSP47.