CRTH2 antagonism in vivo attenuates airway tissue eosinophilia and mucus cell hyperplasia. Above (A): OVA challenge produced marked eosinophilia and mucus cell hyperplasia (***, p < 0.001 compared to saline control). Treatment with ramatroban or the specific CRTH2 antagonist TM30089 significantly reduced airway tissue eosinophilia (black bars) and mucus production (white bars); #, p < 0.05 compared to vehicle treatment. Below (B-G): Light micrographs showing effects in particularly well-responding animals. Lung tissue eosinophilia in normal saline treated lung (B), OVA/vehicle treated lung (C), and OVA/TM30089 treated lung (D). Airway mucus cells are shown in normal saline treated lung (E), OVA/vehicle treated lung (F), and OVA/TM30089 treated lung (G). Scale bar = 100 μm.
Uller et al. Respiratory Research 2007 8:16 doi:10.1186/1465-9921-8-16