Figure 4.

Rapamycin attenuates hypoxia-triggered thickening of the right ventricular wall and hypertrophy of individual cardiomyocytes. Hematoxylin-eosin stained frozen sections of cardiac ventricles were used to estimate the ratio of right ventricular wall area to left ventricular wall area plus septum area [RV/LV+S] (A). The results of a quantitative analysis of the diameters of individual cardiomyocytes of the right and left ventricular wall are given in (B). Data are presented as boxplots (N: normoxia; H: hypobaric hypoxia; CMC: carboxymethylcellulose; Rapa: rapamycin. n = number of animals; * p ≤ 0.05 and ** p ≤ 0.01).