Reference values for exhaled nitric oxide (reveno) study
1 Department of Medicine and Public Health, University of Verona, Italy
2 Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Italy
3 Department of Internal Medicine, University of Brescia, Italy
Respiratory Research 2006, 7:94 doi:10.1186/1465-9921-7-94Published: 30 June 2006
Despite the widespread use of fractional exhaled nitric oxide (FENO) as a biomarker of airways inflammation, there are no published papers describing normal FENO values in a large group of healthy adults.
The aim of this study was to establish adult FENO reference values according to the international guidelines.
FENO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently.
The main result of the study was the significant difference in FENO values between men and women, thus indicating that gender-based reference FENO values are necessary. The FENO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women.
We propose reference FENO values for healthy adult men and women that could be used for clinical and research purposes.