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Human studies investigating angiogenic and angiostatic parameters in patients with idiopathic interstitial pneumonias (1997–2003) |
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| Investigator (year) |
Tissue samples Sample size |
IIP |
Studied Parameters |
Summary |
Limitations |
|
|
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| Keane et al. 41(1997) |
Lung specimens/50 patients/54 controls |
IPF |
CXCL8, 10 |
Increased levels of CXCL8,10 that favor angiogenesis |
Incomplete analysis of the angiogenic network / In vivo micropocket assay |
| Lappi-Blanco et al.53 (1999) |
Lung specimens/19 patients |
IPF-COP |
VWF, CD34+ |
Small sample size / Lack of knowledge regarding factors responsible for vascular heterogeneity |
|
| Meyer et al. 43 (2000) |
BALF samples/32 patients/66 controls |
IPF-CF-SARCO |
VEGF |
Decreased VEGF levels in IPF patients |
Small number of patients / No correlation between serum and BALF levels / No correlation with clinical parameters of disease severity |
| Keane et al. 42 (2001) |
Lung specimens/91 patients/78 controls |
IPF |
CXCL5 |
Increased CXCL5 levels in IPF patients |
Incomplete analysis of the angiogenic network |
| Lappi-Blanco et al. 54(2002) |
Lung specimens/19 patients |
IPF-COP |
VEGF, bFGF |
Increased VEGF and bFGF levels in MB compared to FF |
Small sample size / Lack of knowledge regarding angiostatic regulators |
| Koyama et al. 44 (2002) |
BALF samples/49 patients/27controls |
IPF-PF/CTD-SARCO |
VEGF |
Decreased VEGF levels in IPF patients |
High variability between serum and BALF levels in health and disease |
| Renzoni et al. 45 (2003) |
Lung specimens/17 patients/12 controls |
CFA-SSc |
Vascular density and distribution |
Abnormal vascular distribution in areas proximal to gas exchange / Phenotypically altered vessels |
Morphometric study not suitable to identify the role of angiogenesis in hypoxemia |
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Abbreviations: BALF: Bronchoalveolar lavage fluid, bFGF: basic fibroblast growth factor, CF: Cystic fibrosis, CFA: Cryptogenic fibrosing alveolitis, COP: Cryptogenic organizing pneumonia, FF: Fibroblastic foci, IFN-γ: Interferon gamma, IIPs: Idiopathic Interstitial Pneumonias, IPF: Idiopathic pulmonary fibrosis, MB: Masson bodies, NSIP: Non-specific interstitial pneumonia, PF-CTD: Pulmonary fibrosis associated with a connective tissue disease, SARCO: Sarcoidosis, VEGF: Vascular endothelial growth factor | |||||
Tzouvelekis et al. Respiratory Research 2006 7:82 doi:10.1186/1465-9921-7-82 |
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