Figure 6.

Transcriptional control of IL-6. Luciferase activity following exposure to UVi rhinovirus (UVi), of the IL-6 luciferase promoter construct plasmids in a) non-asthmatic derived HASM cells and b) HASM cells derived from asthmatic donors. The IL-6 promoter construct plasmid with no transcription factor deletions is referred to as full length and the various deletions are indicated by a minus sign in front of the transcription factor binding site. All data sets from each donor are normalised to the constitutive expression of the full-length plasmid, which has been assigned the arbitrary value of 100. * indicates p < 0.05 in the luciferase constructs which contained transcription factor binding site deletions in response to UVi RV-16. n = 6 non-asthmatic and n = 5 asthmatic derived HASM cells.