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Minimal Clinically Important Difference (MCID) for the Clinical COPD Questionnaire (CCQ) by criterion referencing. Differences between baseline (Day 42) CCQ scores are grouped according to major health events during 12-month follow-up. Unpaired-sample t-tests were used for total CCQ scores and for symptom and functional domains, with equal variances assumed; the Mann-Whitney U test was used for the mental domain. |
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| CCQ score category |
Score difference |
||
|
|
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| Mean |
95% confidence interval |
p value |
|
|
|
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| Death (n = 25) or survival (n = 143) |
|||
|
|
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| Total |
-0.80 |
-1.23, -0.37 |
<0.001* |
| Symptoms |
-0.62 |
-1.13, -0.12 |
0.015* |
| Function |
-1.32 |
-1.90, -0.74 |
<0.001* |
| Mental |
0.5§ |
0.211 |
|
|
|
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| Rehospitalization (n = 56) or not (n = 112) |
|||
|
|
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| Total |
-0.18 |
-0.52, 0.16 |
0.290 |
| Symptoms |
-0.07 |
-0.46–0.31 |
0.706 |
| Function |
-0.47 |
-0.93, -0.007 |
0.047* |
| Mental |
0§ |
0.505 |
|
|
|
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| Death/rehospitalization (n = 70) versus survival/no rehospitalization (n = 98) |
|||
|
|
|||
| Total |
-0.39 |
-0.71, -0.07 |
0.017* |
| Symptoms |
-0.27 |
-0.63, 0.10 |
0.153 |
| Function |
-0.77 |
-1.19, -0.34 |
0.001* |
| Mental |
0§ |
0.987 |
|
|
* Statistically significant (2-tailed): p < 0.05. § Difference in median scores COPD = chronic obstructive pulmonary disease. | |||
Kocks et al. Respiratory Research 2006 7:62 doi:10.1186/1465-9921-7-62 |
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