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Minimal Clinically Important Difference (MCID) for the Clinical COPD Questionnaire (CCQ) by patient referencing. Differences between CCQ scores for Days 1 and 2 grouped according to Global Rating of Change (GRC) as scored by patients on a scale of -7 to 7. Note that paired-sample t-tests were used for total CCQ scores and for symptom and functional domains; Wilcoxon signed rank test was used for the mental domain. |
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| CCQ score category |
Score difference: Day 1 minus Day 2 |
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| Mean ± SD |
95% confidence interval |
p value |
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| GRC +1 (n = 3) |
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| Total |
0.30 ± 0.30 |
-0.45, 1.05 |
0.225 |
| Symptoms |
-0.25 ± 1.64 |
-4.32, 3.82 |
0.816 |
| Function |
1.17 ± 0.80 |
-0.83, 3.16 |
0.128 |
| Mental |
-0.5§ |
0.157 |
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| GRC +2 to +3 (n = 15) |
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| Total |
0.40 ± 0.90 |
-0.09, 0.91 |
0.098 |
| Symptoms |
0.70 ± 1.09 |
0.98, 1.30 |
0.026* |
| Function |
0.17 ± 1.37 |
-0.93, 0.59 |
0.645 |
| Mental |
1.0§ |
0.007* |
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| GRC +4 to +5 (n = 14) |
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| Total |
1.31 ± 1.09 |
0.69, 1.94 |
0.001* |
| Symptoms |
1.13 ± 1.52 |
0.25, 2.0 |
0.016* |
| Function |
1.48 ± 1.25 |
0.76, 2.20 |
0.001* |
| Mental |
0.5§ |
0.018* |
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| GRC +6 to +7 (n = 2) |
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| Total |
1.95 ± 0.07 |
1.31, 2.59 |
0.016* |
| Symptoms |
2.75 ± 1.77 |
-13.13, 18.63 |
0.272 |
| Function |
1.50 ± 1.06 |
-8.03, 11.03 |
0.295 |
| Mental |
1.25§ |
0.317 |
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* Statistically significant (2-tailed): p < 0.05. § Difference in median scores COPD = chronic obstructive pulmonary disease; SD = standard deviation. | |||
Kocks et al. Respiratory Research 2006 7:62 doi:10.1186/1465-9921-7-62 |
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