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Association between CD4 cell count and IFN-γ release in response to PHA. |
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| CD4 cell counts1) |
No of patients |
Number and percentage of PHA non-responders |
IFN-γ release (Median and 25–75 percentile) |
|
|
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| <100 |
17 |
4 (24%)* |
1,53 (0,34-19,49)# |
| 100–199 |
37 |
1 (3%) |
11.58 (3,88-30,11) |
| 200–299 |
63 |
5 (8%) |
16,78 (9,40-25,20) |
| >300 |
473 |
10 (2%) |
20,35 (13,20–31,00) |
|
1) cells/μl * p < 0.0005, difference in the proportion of PHA-non-responders between patients with a CD4 cell count higher or lower than 100 cells/μL (Chi-Square test). # p = 0.0001 difference in the median IFN-γ release between patients with a CD4 cell count < 100 compared to groups of patients with a CD4 cell count ≥ 100 cells/μL (Mann-Withney U test) and there was a trend for increasing INF-γ release for increasing CD4 group (non-parametric test for trend across ordered groups (p < 0.0001). | |||
Brock et al. Respiratory Research 2006 7:56 doi:10.1186/1465-9921-7-56 |
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