|
Identification of risk factors for LTBI among HIV positive |
||||
| QTF negative (n = 543) |
QTF positive (n = 27) |
OR, (95% CI) |
P values |
|
|
|
||||
| Age, median years (25th–75th quartile) |
43 (38–50) |
42 (36–49) |
P = 0.05 |
|
| Male sex, no (%) |
405 (75) |
17 (63) |
||
| Tuberculosis |
||||
| Previous TB diagnosis no. (%) |
22 (4) |
5 (19) |
4.9 (1.7–14.1) |
p= 0.0063 |
| Tuberculosis risk factors, no. (%) |
||||
| History of exposure |
43 (8) |
8 (30) |
4.9 (2.0–11.8) |
p= 0.001154 |
| Long term residence in a TB endemic country a |
98 (17) |
15 (56) |
5.7 (2.6–12.5) |
p= 0.000021 |
| IVDU b |
59 (11) |
5 (19) |
P= 0.110 |
|
| ≥1 risk factor |
184 (34) |
21 (78) |
7.2 (2.9–18.2) |
p= 0.000003 |
| HIV status |
||||
| Age at HIV diagnosis, median years (25th–75th quartile) |
34 (28–41) |
34 (29–40) |
P = 0.11 |
|
| Years with HIV diagnosis, median years (25th–75th quartile) |
8.5 (4–14) |
7 (4–11.0) |
P = 0.10 |
|
| AIDS diagnosed, no (%) |
107 (20) |
6 (22) |
P = 0.18 |
|
| HAART treatment, no (%) |
416 (77) |
19 (70) |
P = 0.13 |
|
| CD4 cell count, mean (± s.d.) |
523 (± 273) |
600 (± 274) |
P = 0.17 |
|
| 0–99 CD4 cells/μL, (%) |
13 (2) |
0 (0) |
||
| 100–199 CD4 cells/μL, (%) |
35 (6) |
1 (4) |
||
| 200–300 CD4 cells/μL, (%) |
55 (10) |
2 (7) |
||
| >300 CD4 cells/μL,l |
440 (81) |
24 (89) |
||
| HIV RNA, no (%) |
||||
| <500 copies per ml |
412 (76) |
18 (67) |
0.10 |
|
| 500 – 50,000 copies per ml |
79 (15) |
8 (30) |
||
| >50,000 copies per ml |
52 (10) |
1 (4) |
||
| Factors presumed to influence immune status |
||||
| Diabetes, no. (%) |
18 (3) |
2 (7) |
0.18 |
|
| Alc. Abuse, no (%) |
59 (11) |
3 (11) |
0.24 |
|
|
aIncidence >25/100,000. bIntravenous drug user Differences between media n values were analysed using Mann-Withney test, and differences between proportions using Chi Square test | ||||
Brock et al. Respiratory Research 2006 7:56 doi:10.1186/1465-9921-7-56 |
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