Table 2

Association of maternal atopy* with decreased Foxp3 expression following Ppg stimulation in CBMC.

Parameter

No maternal atopy (Median, 25/75)

Maternal atopy (Median, 25/75)

P value (Mann-Whitney rank)


Foxp3

1.59 (-0.4/3.26)

-0.6 (-0.78/1.06)

0.049

GITR

1.22 (-0.17/4.28)

2.74 (-0.40/7.21)

0.43

CTLA4

1.19 (-0.22/2.02)

- 0.13 (-0.77/0.79)

0.17


* Maternal atopy was defined as history of doctors diagnosis of one or more of the diagnoses asthma, hay fever or eczema. N = 31 mothers without and n = 19 mothers with atopy (differs slightly in groups depending on availability of data).

The mRNA level of the genes is shown as fold difference in gene expression in stimulated as compared to unstimulated samples and compared to the housekeeping gene GAPDH. Quantitative gene expression was assessed with real-time RT-PCR.

Schaub et al. Respiratory Research 2006 7:40   doi:10.1186/1465-9921-7-40

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