Table 1

Association of maternal atopy* with decreased IL-10 production following innate stimulation (Ppg) in CBMC.

Parameter

Stimulus

No maternal atopy (Median, 25/75%)

Maternal atopy (Median, 25/75%)

P value (Mann-Whitney rank)


SI

Ppg

1.67 (0.99/2.41)

1.45 (1.13/2.75)

0.97

Der f1

1.43 (0.98/2.35)

1.38 (0.93/1.95)

0.93


IFN-γ

U

2.49 (1.05/5.83)

2.89 (1.86/4.37)

0.57

Ppg

7.53 (4.70/136.20)

6.07 (2.71/19.19)

0.22

D

3.70 (1.25/22.38)

9.48 (2.46/18.60)

0.73

IL-13

U

0.01 (0.01/3.39)

0.01 (0.01/3.69)

0.58

Ppg

8.04 (0.01/46.04)

6.50 (0.01/61.04)

0.91

D

0.01 (0.01/16.78)

4.10 (0.01/16.96)

0.64


TNF-α

U

2.25 (0.01/176.85)

0.27 (0.01/7.60)

0.17

Ppg

1474.00 (1295.50/1645.00)

1529.00 (1069.12/1694.25)

0.87

D

758.30 (205.25/1340.25)

782.50 (168.30/1470.00)

0.96


IL-10

U

1.01 (0.52/2.24)

0.38 (0.01/0.77)

0.007

Ppg

69.54 (25.92/239.78)

13.47 (9.12/86.22)

0.03

D

10.28 (4.15/14.92)

6.51 (4.25/13.80)

0.68


* Maternal atopy was defined as history of doctors diagnosis of one or more of the diagnoses asthma, hay fever or eczema. N = 31 mothers without and n = 19 mothers with atopy (differs slightly in groups depending on availability of data).

Lymphocyte proliferation is shown as SI (stimulation index, ratio of mean counts per minute of stimulated over unstimulated replicates). Cytokine concentrations were measured with ELISA and are presented in pg/ml.

Schaub et al. Respiratory Research 2006 7:40   doi:10.1186/1465-9921-7-40

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