Figure 1.

KCNQ channel blockers constrict pulmonary, but not mesenteric artery. Original records of tension developed by rat (A, B) and mouse (C, D) intrapulmonary artery (IPA) in the presence of 50 mM KCl or increasing concentrations of linopirdine or XE991, applied where indicated. Original records of tension developed by rat (E) and mouse (F) mesenteric arteries (MA) show responses to 50 mM KCl, but not linopirdine or XE991 applied at the same concentrations. Calibration bars are 1 mN (vertical) and 10 min (horizontal).