Figure 6.

Ultrastructure of tracheal hemidesmosomes. Tracheas from P1-2 Lamc2-/- and littermate control mice were processed for transmission electron microscopy. Littermate control tracheas (a) had well-defined, organized hemidesmosomes with darkened areas in the lamina densa abutting the hemidesmosome (arrows). In contrast, hemidesmosomes in Lamc2-/- tracheas (b) were less organized, the intracellular component was more diffuse, and the lamina densa directly below the hemidesmosomal areas lacked the electron density seen in the littermate control (arrows).