Wnt signalling in lung development and diseases

Judit E Pongracz¹^,2 and Robert A Stockley³

¹Department of Immunology and Biotechnology, University of Pécs, Pécs, Hungary

²Institute for Biomedical Research, University of Birmingham, Birmingham, UK

³Department of Medicine, University of Birmingham, Birmingham, UK

author email corresponding author email

Respiratory Research 2006, 7:15doi:10.1186/1465-9921-7-15


Published:	26 January 2006

Abstract

There are several signalling pathways involved in lung organogenesis including Notch, TGFβ /BMP, Sonic hedgehog (Shh), FGF, EGF, and Wnt. Despite the widely acknowledged significance of Wnt signalling in embryonic lung development, the role of different Wnt pathways in lung pathologies has been slow to emerge.

In this review, we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary diseases.