Table 2

Mean difference in pre-bronchodilator FEV1 between treatment with salmeterol and with placebo/usual therapy after 3, 6 and 12 months of treatment (intent to treat population).
Study
 No. of subjects
 Mean treatment effect on pre-bronchodilator FEV1 (ml)


Salmeterol
 Placebo
 3 months
 P value
 6 months
 P value
 12 months
 P value
van Noord
 49
 50
 108
 0.0056
 -
 -
 -
 -
Rennard
 131
 133
 74
 0.0027
 -
 -
 -
 -
Mahler
 135
 143
 128
 <0.0001
 -
 -
 -
 -
Boyd
 228
 227
 102
 <0.0001
 -
 -
 -
 -
Mahler
 164
 185
 96
 <0.0001
 94
 <0.0001
 -
 -
Hanania
 176
 185
 97
 <0.0001
 92
 <0.0001
 -
 -
Chapman
 201
 206
 42
 0.0278
 20
 0.3559
 -
 -
Calverley
 372
 361
 80
 <0.0001
 91
 <0.0001
 61
 0.0022
Stockley
 316
 318
 81
 <0.0001
 74
 0.0002
 96
 <0.0001
Pooled
 1772
 1808
 86
 <0.0001
 75
 <0.0001
 73
 <0.0001

-: not applicable

Stockley et al. Respiratory Research 2006 7:147   doi:10.1186/1465-9921-7-147