|
Associations between reflux symptoms and respiratory outcomes in atopic and non-atopic Study members. |
|||||||||
| Heartburn |
Regurgitation |
Heartburn and Regurgitation |
|||||||
|
|
|||||||||
| Non-atopic |
Atopic |
Non-atopic |
Atopic |
Non-atopic |
Atopic |
||||
|
|
|||||||||
| OR (95% CI) |
OR (95% CI) |
p-itn |
OR (95% CI) |
OR (95% CI) |
p-itn |
OR (95% CI) |
OR (95% CI) |
p-itn |
|
|
|
|||||||||
| Asthma |
1.81 (0.64, 5.17) |
1.96 (1.12, 3.44) |
0.873 |
4.03 (1.11, 14.5) |
2.54 (1.23, 5.24) |
0.603 |
3.51 (0.80, 15.3) |
3.16 (1.35, 7.38) |
0.827 |
| Wheeze |
2.88 (1.40, 5.90) |
1.30 (0.76, 2.20) |
0.072 |
7.27 (2.23, 23.7) |
1.93 (0.95, 3.93) |
0.062 |
6.56 (1.68, 25.6) |
2.54 (1.07, 6.00) |
0.253 |
| Cough |
4.67 (1.98, 11.0) |
1.46 (0.73, 2.92) |
0.039 |
5.90 (1.94, 18.0) |
2.88 (1.30, 6.38) |
0.315 |
10.8 (3.02, 38.6) |
2.87 (1.12, 7.34) |
0.099 |
| BDR |
2.81 (0.70, 11.3) |
2.08 (0.99, 4.36) |
0.760 |
7.57 (1.76, 32.5) |
1.76 (0.64, 4.86) |
0.108 |
12.7 (2.71, 59.6) |
2.08 (0.67, 6.50) |
0.067 |
| Coeff (95% CI) |
Coeff (95% CI) |
Coeff (95% CI) |
Coeff (95% CI) |
Coeff (95% CI) |
Coeff (95% CI) |
||||
|
|
|||||||||
| FEV1/FVC |
0.80 (-1.24, 2.84) |
-1.15 (-3.13, -0.82) |
0.213 |
-2.43 (-5.37, 0.51) |
-2.27 (-4.95, 0.41) |
0.940 |
-1.91 (-5.34, -1.51) |
-2.56 (-5.79, 0.66) |
0.808 |
|
Non-atopic groups (n = 278) and atopic (n = 536) defined by skin-prick tests at age 21. The FEV1/FVC ratio is analysed by linear regression. All other analyses use logistic regression. Analyses use the respiratory outcomes as the dependent variables and are adjusted for BMI and sex. OR = odds ratio, Coeff = coefficient, 95% CI = 95% confidence intervals, p-itn = p value for interaction between atopic status and reflux symptoms, BDR = 10% or greater increase in FEV1 following salbutamol. | |||||||||
Hancox et al. Respiratory Research 2006 7:142 doi:10.1186/1465-9921-7-142 |
|||||||||