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Protease-antiprotease interactions |
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| Proteinase |
Class |
Activity |
Active antiproteases |
|
|
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| Neutrophil elastase |
Serine |
Degrades elastin, collagen type IV & laminin |
AAT |
| Inactivates TIMP |
SERPINA3 |
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| Activates MMP9 |
SLPI |
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| Cathepsin G |
Serine |
Degrades elastin, collagen I, II, IV & laminin |
SERPINA3 |
| Activates MMP9 |
SLPI |
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| Proteinase 3 |
Serine |
Degrades elastin & collagen IV |
AAT |
| Activates TNFα |
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| Cathepsin B |
Cysteine |
Degrades elastin |
Cystatin C |
| Inactivates secretory leukocyte proteinase inhibitor (SLPI) |
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| MMP1 |
MMP |
Degrades collagens I-IV, VII, VIII, X, XI |
TIMP1-4 |
| Inactivates AAT |
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| Activates TNFα |
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| MMP9 |
MMP |
Degrades collagen IV, V, X, XIV & elastin |
TIMP1-4 |
| Inactivates AAT |
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| Activates TNFα & TGFβ |
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| MMP12 |
MMP |
Degrades collagen I, IV, elastin & fibrillin |
TIMP1-4 |
| Inactivates AAT |
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| Activates TNFα |
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Wood and Stockley Respiratory Research 2006 7:130 doi:10.1186/1465-9921-7-130 |
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