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Cell infiltration in LPS-exposed PPARα+/+ and PPARα-/- mice treated with fenofibrate. |
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| Group |
Number of cells (×106) |
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|
|
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| Total |
Neutrophils |
Macrophages |
|
|
|
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| (+/+)-LPS-CMC |
1.93 ± 0.11 |
0.95 ± 0.11 |
0.98 ± 0.13 |
| (+/+)-LPS-FF |
0.73 ± 0.08 (*) |
0.23 ± 0.07 (*) |
0.50 ± 0.05 (*) |
| (-/-)-LPS-CMC |
3.46 ± 0.38 (*) |
1.85 ± 0.28 (*) |
1.60 ± 0.25 (*) |
| (-/-)-LPS-FF |
3.13 ± 0.54 (n.s.) |
1.73 ± 0.30 (n.s.) |
1.39 ± 0.28 (n.s.) |
|
Data are mean ± SEM of n = 6–8 animals. (*): statistically significant differences at α = 0.05 when compared to PPARα+/+ mice treated with CMC. (n.s.): non statistically different when compared to PPARα-/- mice treated with CMC. | |||
Delayre-Orthez et al. Respiratory Research 2005 6:91 doi:10.1186/1465-9921-6-91 |
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