CC-chemokine mRNA expression 8 h (A) and 24 h (B) after treatment with anti-Fas mAb or isotype control (IgG). Two days post allergen challenge expression of 5 different CC-chemokines in the lung was up-regulated compared to immunized control animals receiving saline challenges. Treatment with anti-Fas mAb post allergen challenge further increased the expression of eotaxin MIP-1α, and MIP -1β, and additionally induced the expression of IP-10 and MCP-1. Data are mean ± SEM. **p < 0.01 indicates differences between OVA and saline treatments. §§ p < 0.01 indicates difference between anti-Fas mAb treated and control-treated OVA-challenged animals.
Uller et al. Respiratory Research 2005 6:90 doi:10.1186/1465-9921-6-90