Table 2

List of studied serum biomarkers in ILDs

Lung epithelium-specific proteins
Surfactant-associated proteins

     • SP-A

     • SP-D

Mucin-associated antigens

     • KL-6/MUC1

Clara-cell protein

     • CC16

Other lung epithelial markers

     • CK-19

     • Ca 19-9

     • SLX
Cytokines and other serological parameters
Chemokines and cytokines

     • MCP-1

     • MIP-1a

     • ITAC/CXCL-11

     • TNF

Anti-oxidant enzymes and collagen peptides

     • Glutathione

     • Type III procollagen peptide

Markers of T-cell activation

     • sIL-2R

Markers of macrophage/monocyte activity

     • ACE

     • Neopterin

     • b-glucuronidase

     • LDH

Abbreviations: ACE: Angiotensin Converting Enzyme, Ca 19-9: Carbohydrate antigen Sialyl Lewis (a), CC16: Clara-cell protein 16, CK19: Cytokeratin fragment 19, CXCL-11: CXC chemokine 11, KL-6: Krebs von den Lungen-6, LDH: Lactate Dehydrogenase, MCP-1: Monocyte Chemoattractant Protein-1, MIP-1a: Monocyte Inflammatory Protein-1a, MUC: Mucin, ILDs: Interstitial Lung Diseases, ITAC: Interferon-inducible T cell-a chemoattractant, sIL-2R: soluble interleukin-2 receptor, SLX: Carbohydrate antigen Sialyl Lewis (x), TNF: Tumor Necrosis Factor

Tzouvelekis et al. Respiratory Research 2005 6:78   doi:10.1186/1465-9921-6-78