Table 1

Summarized data of hemodynamics and blood gases in rabbits with U46619-induced pulmonary hypertension and inhalation of iloprost in the absence and presence of sub-threshold intravenous PDE inhibitors.Δ

Control/U46619
 U46619/Ilo
 U46619/Ilo/Sil
 U46619/Ilo/8MM-IBMX
 U46619/Ilo/Mota
 U46619/Ilo/8MM-IBMX/Sil
 U46619/Ilo/Mota/Sil

Pre
 post
 pre
 post
 pre
 post
 pre
 post
 pre
 post
 pre
 post
 pre
 post
PSA, mmHg
 111 ± 4
 105 ± 3
 111 ± 3
 111 ± 3
 106 ± 3
 105 ± 2
 107 ± 2
 104 ± 4
 100 ± 3
 96 ± 3
 99 ± 3
 97 ± 2
 93 ± 4
 92 ± 4
PPA, mmHg
 15.9 ± 0.3
 25.9* ± 0.4
 25.8 ± 0.6
 22.7* ± 0.4
 25.7 ± 0.2
 21.8* ± 0.3
 24.8 ± 0.7
 21.1* ± 0.8
 27.3 ± 1,1
 21.0* ± 0.6
 25.0 ± 0.4
 20.4* ± 0.3
 24.7 ± 0.4
 19.3* ± 0.4
CO, ml/min
 555 ± 23
 544 ± 38
 432 ± 27
 452 ± 25
 444 ± 19
 488 ± 35
 393 ± 24
 437 ± 29
 417 ± 21
 446 ± 15
 454 ± 27
 505 ± 30
 501 ± 35
 555 ± 52
PAOP, mmHg
 7.2 ± 1.2
 7.6 ± 0.8
 8.0 ± 1.1
 7.3 ± 1.3
 7.7 ± 0.9
 7.4 ± 1.1
 7.7 ± 0.8
 7.6 ± 1.2
 6.9 ± 1.3
 7.3 ± 1.1
 7.7 ± 1.2
 7.7 ± 1.1
 7.8 ± 0.8
 7.2 ± 1.1
PVRI, dyne/s cm-5 m2
 275 ± 34
 592* ± 49
 725 ± 39
 599* ± 37
 713 ± 58
 519* ± 44
 765 ± 67
 543* ± 63
 861 ± 64
 540* ± 71
 670 ± 75
 442* ± 52
 593 ± 56
 383* ± 61
PaO2, mmHg
 226 ± 17
 199 ± 12
 183 ± 12
 177 ± 10
 191 ± 6
 203 ± 4
 228 ± 7
 188 ± 12
 201 ± 7
 197 ± 11
 171 ± 10
 173 ± 11
 179 ± 10
 174 ± 14
PHa
 7.42 ± 0.02
 7.35 ± 0.02
 7.37 ± 0.03
 7.32 ± 0.01
 7.36 ± 0.02
 7.32 ± 0.02
 7.41 ± 0.02
 7.38 ± 0.02
 7.33 ± 0.01
 7.31 ± 0.01
 7.35 ± 0.02
 7.34 ± 0.02
 7.33 ± 0.02
 7.29 ± 0.01
PaCO2 mmHg
 42.7 ± 1.3
 43.0 ± 3.5
 41.5 ± 2.0
 40.7 ± 1.0
 42.0 ± 4.1
 45.2 ± 4.0
 36.2 ± 1.6
 37.7 ± 1.5
 44.3 ± 1.2
 46.2 ± 1.2
 45.9 ± 1.7
 47.6 ± 1.4
 36.9 ± 2.0
 38.0 ± 1.8
PvO2, mmHg
 46.7 ± 1.3
 44.1 ± 2.4
 39.9 ± 1.7
 42.6 ± 1.2
 39.7 ± 2.3
 44.9 ± 1.4
 35.8 ± 1.5
 39.7 ± 2.1
 40.7 ± 1.64
 42.7 ± 1.2
 39.7 ± 2.5
 44.9 ± 2.6
 41.8 ± 1.2
 44.0 ± 1.6
PHv
 7.30 ± 0.01
 7.24 ± 0.02
 7.34 ± 0.03
 7.29 ± 0.01
 7.23 ± 0.02
 7.20 ± 0.02
 7.37 ± 0.02
 7.31 ± 0.03
 7.28 ± 0.01
 7.26 ± 0.01
 7.29 ± 0.02
 7.28 ± 0.02
 7.28 ± 0.02
 7.24 ± 0.01
PvCO2, mmHg
 49.8 ± 0.9
 54.9 ± 1.2
 48.9 ± 2.3
 49.7 ± 1.1
 59.2 ± 1.6
 60.6 ± 1.4
 44.6 ± 2.5
 44.9 ± 2.5
 52.4 ± 1.4
 54.2 ± 1.4
 53.8 ± 2.0
 52.9 ± 2.2
 42.5 ± 2.3
 45.9 ± 1.6

Δ PSA, mean aortic pressure; PPA, mean pulmonary artery pressure; CO, cardiac output; PAOP, pulmonary artery occlusion pressure; PVR, pulmonary vascular resistance; PaO2, arterial PO2; pHa, arterial pH; PaCO2, arterial PCO2; PvO2, central venous PO2; pHv, central venous pH; PvCO2, central venous PCO2; Ilo, iloprost; Sil, sildenafil; 8MM-IBMX, 8-Methoxymethyl-3-isobutyl-1-methylxanthine; Mota, motapizone. The first two columns give summarized data for all groups. All other columns give pre- and post-iloprost nebulization data in animals undergoing preceding sub-threshold PDE-inhibitor infusion (n = 8 for each group). Asterisks indicate significant differences between pre and post-aerosolization values (* = p < 0.05).

Schermuly et al. Respiratory Research 2005 6:76   doi:10.1186/1465-9921-6-76