Figure 5.

Influence of PDE inhibition on the area under the curve (AUC) of iloprost-induced decrease in pulmonary artery pressure (P_PA). Measurements were performed from onset of iloprost nebulization (Ilo aer) until 68 min post aerosolization. AUC was calculated by standard techniques and is given as %ΔP_PA × min. The maneuvers and dosages correspond to those depicted in Fig. 2. *, p < 0.05 as compared to sole iloprost nebulization; †, p < 0.05 as compared to all other groups.