Figure 2.

Influence of iloprost nebulization and its combination with sub-threshold doses of single (a) or combined (b) intravenous PDE inhibitors on U46619-elicted pulmonary hypertension. Pulmonary artery pressure (P_PA, in % of U46619-induced increase) is given (mean ± SEM of 8 independent experiments each, SEM bars are missing when falling into symbol). Iloprost nebulization (Ilo aer; 0.4 μg/kg) is indicated by the horizontal bar. The PDE inhibitors were pre-applied as short-term infusion as follows: 200 μg/kg × min 8-Methoxymethyl-IBMX, 1 μg/kg × min sildenafil, 5 μg/kg × min motapizone.