Figure 1.

Dose effect curves of different PDE inhibitors on U46619-elicited pulmonary hypertension (a) and systemic arterial pressure (b). (a) Pulmonary artery pressure drop (ΔP_PA, in mmHg) and systemic arterial pressure drop (ΔP_SA, in mmHg) (b) are given (mean ± SEM of 6 independent experiments each). PDE-inhibitors were applied in different doses as short-term infusion.