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Studies measuring cytokines in patients with or at risk for ARDS |
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| Investigator |
Patients Controls |
Biomarker / Summary |
ROC curve analysis Cut-off values |
Specificity – Sensitivity PPV – NPV |
Limitations |
|
|
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| Pinsky et al. 13 |
52 at risk |
Relation of IL-6 and TNF plasma levels to multiple-system organ failure and mortality |
No |
Not estimated |
Small number of patients No ROC curve analysis / cut-off levels No serial measurement |
| Takala et al. 14 |
20 at risk 56 controls |
IL-6 and IL-8 plasma levels predict organ failure in community-acquired septic shock |
No |
Not estimated |
Small number of patients No ROC curve analysis / cut-off levels Poor discriminative value of serum biomarkers per se |
| Calandra et al. 15 |
70 at risk |
IL-6 plasma levels do not predict the outcome in at risk patients for ARDS |
No |
Not reported |
Small number of patients No ROC curve analysis |
| Kiehl et al. 16 |
19 at risk |
TNFa, IL-6, IL-8 plasma levels fail to associate with severity and course of ARDS in leukocytopenic patients |
No |
Not estimated |
Small number of patients No ROC curve analysis / cut-off levels Leukocytopenic patients |
| Meduri et al. 18 |
27 ARDS |
TNFa, IL-1β, IL-2, IL-4, IL-6, IL-8 Superiority of IL-1β and IL-6 plasma levels in monitoring disease activity over commonly applied clinicophysiologic parameters. |
Yes TNFa: 400 pg/ml IL-1β: 400 pg/ml IL-2: 200 pg/ml IL-4: 200 pg/ml IL-6: 400 pg/ml IL-8: 400 pg/ml |
TNFa: 89-50-85-57% IL-1β: 78-83-83-78% IL-2: 89-83-90-80% IL-4: 89-50-85-57% IL-6: 77-75-81-70% IL-8: 66-50-66-50% |
Small number of patients Perspective study Overlap of cytokine levels between survivors and non-survivors Heterogeneity of studied population Definition criteria of ARDS |
| Agouridakis et al. 19 |
8 ARDSa 26 at risk |
Association between increased levels of IL-2 and IL-15 and outcome in patients with early ARDS |
Yes IL-2: 173 pg/ml IL-15: 250 pg/ml |
IL-2: 100-100-100-100% IL-15: 100-100-100-100% |
Small number of patients Limited number of studied molecules |
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Abbreviations: ARDS: Acute Respiratory Distress Syndrome, BALF: Bronchoalveolar lavage Fluid, IL: Interleukin, NPV: Negative Predictive Value, PPV: Positive Predictive Value, ROC: Receiver Operating Characteristic, sIL-2R: soluble interleukin-2 receptor, TNFa: Tumor Necrosis Factor-alpha a: Use the American European Consensus Conference definitions | |||||
Tzouvelekis et al. Respiratory Research 2005 6:62 doi:10.1186/1465-9921-6-62 |
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