Table 5

Vital signs at baseline (before pre challenge spirometry), and the change (Δ) at end of challenge and during recovery for the safety population

Parameter
Challenge Point
Mannitol
Hypertonic Saline

n

627
636
Heart Rate (beats/ minute)
Baseline
75.9 ± 13.4
76.2 ± 13.6

End Challenge
Δ7.2 ± 10.8
Δ5.4 ± 9.2

Recovery to pre Challenge FEV1 or 15 min post Challenge
Δ1.6 ± 10.0
Δ0.7 ± 9.3
Respiration Rate (per min)
Baseline
17.1 ± 4.3
17.1 ± 4.3

End Challenge
Δ1.0 ± 3.3
Δ1.1 ± 3.7

Recovery to pre Challenge FEV1 or 15 min post Challenge
Δ0.1 ± 2.9
Δ0.2 ± 3.0
Systolic Blood Pressure
Baseline
117.0 ± 14.8
116.9 ± 14.6
mm Hg
End Challenge
Δ1.5 ± 9.5
Δ1.5 ± 9.2

Recovery to pre Challenge FEV1 or 15 min post Challenge
Δ-0.1 ± 8.8
Δ0.5 ± 9.1
Diastolic Blood Pressure
Baseline
72.0 ± 10.0
72.6 ± 10.2
mmHg
End Challenge
Δ2.4 ± 7.5
Δ1.7 ± 7.4

Recovery to pre Challenge FEV1 or 15 min post Challenge
Δ1.2 ± 7.0
Δ0.4 ± 7.3
% oxygen saturation by
Baseline
97.2 ± 1.8
97.5 ± 1.6
pulse oximeter
End Challenge
Δ0.8 ± 2.0
Δ-0.7 ± 1.9

Recovery to pre Challenge FEV1 or 15 min post Challenge
Δ-0.4 ± 1.6
Δ-0.1.4 ± 1.6

Brannan et al. Respiratory Research 2005 6:144   doi:10.1186/1465-9921-6-144