Table 2

Olfactory epithelial and lung manganese concentrations in young monkeys following exposure to air or MnSO4. Manganese concentrations were determined by graphite furnace atomic absorption spectrometry and are expressed as mean ± SEM μg Mn/g tissue wet weight. Young male rhesus monkeys (n = 4 except where noted) were exposed to either air or MnSO4 6 hours/day, 5 days/week.
Tissue
 MnSO4 exposure concentration (mg Mn/m3)
 15
 33
 Exposure Day 65
 65 [+45]a
 65 [+90]a
Olfactory epithelium
 0

0.42 ± 0.01b


0.06

1.22 ± 0.15*b


0.3

2.96 ± 0.46*


1.5
 6.10 ± 0.39*
 7.34 ± 0.70*
 7.10 ± 2.01*
 0.65 ± 0.04
 0.69 ± 0.11
Lung
 0

0.15 ± 0.03b


0.06

0.18 ± 0.01b


0.3

0.25 ± 0.02*


1.5
 0.39 ± 0.06*
 0.35 ± 0.02*
 0.33 ± 0.04*
 0.09 ± 0.01
 0.06 ± 0.01

a Number in brackets indicates number of days post exposure assessment.

b n = 6.

* p < 0.05

Dorman et al. Respiratory Research 2005 6:121   doi:10.1186/1465-9921-6-121