|
Protein levels of eotaxin, MCP-1, RANTES, and IL-6 in the lung tissuesupernatants. |
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| Group |
Animals |
eotaxin |
MCP-1 |
RANTES |
IL-6 |
|
|
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| (n) |
(pg/total lung tissue supernatants) |
||||
|
|
|||||
| vehicle |
16 |
67.9 ± 2.9 |
20.8 ± 3.5 |
174.6 ± 15.8 |
105.8 ± 3.6 |
| 14 nm |
13 |
99.4 ± 7.1 |
239.0 ± 17.4** |
192.3 ± 18.0 |
151.7 ± 8.2 |
| 56 nm |
14 |
89.5 ± 9.2 |
89.3 ± 7.4 |
201.6 ± 22.1 |
106.5 ± 4.9 |
| OVA |
16 |
130.9 ± 32.3 |
41.9 ± 9.2 |
160.7 ± 17.1 |
118.3 ± 5.7 |
| OVA + 14 nm |
16 |
804.8 ± 175.7** ## $$ |
542.8 ± 45.4** ## $$ |
432.6 ± 27.8** ## $$ |
297.7 ± 30.2** ## $$ |
| OVA + 56 nm |
17 |
399.1 ± 86.9** # $ |
124.0 ± 14.1** # |
235.4 ± 16.8* # |
202.4 ± 54.2** # $$ |
|
Six groups were intratracheally inoculated with vehicle, nano particles, OVA, or the combination of OVA and nano particles for 6 wk. Lungs were removed and frozen 24 h after the last intratracheal administration. Protein levels in the lung tissue supernatants were analyzed using ELISA. Results are shown as mean ± SEM. *P < 0.05 versus vehicle, **P < 0.01 versus vehicle, #P < 0.05 versus OVA, ##P < 0.01 versus OVA. $P < 0.05 versus nano particles. $$P < 0.01 versus nano particles. | |||||
Inoue et al. Respiratory Research 2005 6:106 doi:10.1186/1465-9921-6-106 |
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