|
Protein levels of Th2 cytokines in the lung tissue supernatants. |
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| Group |
Animals |
IL-5 |
IL-13 |
IL-4 |
|
|
||||
| (n) |
(pg/total lung tissue supernatants) |
|||
|
|
||||
| vehicle |
16 |
5.5 ± 1.1 |
4.0 ± 1.1 |
204.3 ± 13.1 |
| 14 nm |
13 |
4.6 ± 1.9 |
7.4 ± 4.3 |
194.7 ± 12.8 |
| 56 nm |
14 |
7.1 ± 1.9 |
21.1 ± 8.9 |
204.3 ± 12.5 |
| OVA |
16 |
26.8 ± 11.1 |
16.2 ± 7.3 |
216.5 ± 14.8 |
| OVA + 14 nm |
16 |
113.7 ± 32.0** ## $ |
120.3 ± 42.4** ## $ |
178.5 ± 16.2 |
| OVA + 56 nm |
17 |
88.8 ± 38.0** # $ |
61.8 ± 27.5* |
170.8 ± 17.6# |
|
Six groups were intratracheally inoculated with vehicle, nano particles, OVA, or the combination of OVA and nano particles for 6 wk. Lungs were removed and frozen 24 h after the last intratracheal administration. Protein levels in the lung tissue supernatants were analyzed using ELISA. Results are shown as mean ± SEM. *P < 0.05 versus vehicle, **P < 0.01 versus vehicle, #P < 0.05 versus OVA, ##P < 0.01 versus OVA. $P < 0.05 versus nano particles. $P < 0.01 versus nano particles. | ||||
Inoue et al. Respiratory Research 2005 6:106 doi:10.1186/1465-9921-6-106 |
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