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TGFβ-regulated signalling and ECM/cytoskeletal genes in control and fibrotic lung fibroblasts |
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| Gene Symbol |
Affymetrix Probe N |
Control LF* |
Fibrotic LF* |
Gene name |
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| Signal transduction |
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| ACVR1 |
39764_at |
2.2 |
1.7 |
activin A receptor, type I |
| ADM |
34777_at |
0.3 |
0.4 |
adrenomedullin |
| AGTR1 |
346_s_at |
3.8 |
3.2 |
angiotensin II receptor, type 1 |
| AGTR1 |
37983_at |
5.1 |
5.9 |
angiotensin II receptor, type 1 |
| BDKRB2 |
39310_at |
0.4 |
0.4 |
bradykinin receptor B2 |
| BMP4 |
1114_at |
0.2 |
0.2 |
bone morphogenetic protein 4 |
| BMP4 |
40333_at |
0.1 |
0.3 |
bone morphogenetic protein 4 |
| DYRK2 |
40604_at |
3.0 |
3.0 |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| DYRK2 |
760_at |
2.9 |
3.3 |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| DYRK2 |
761_g_at |
3.3 |
2.2 |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| MLP |
36174_at |
2.4 |
1.7 |
MARCKS-like protein |
| PLK2 |
41544_at |
0.4 |
0.6 |
polo-like kinase 2 (Drosophila) |
| RRAD |
1776_at |
3.0 |
5.2 |
Ras-related associated with diabetes |
| RRAD |
39528_at |
3.6 |
5.1 |
Ras-related associated with diabetes |
| SMAD3 |
38944_at |
0.4 |
0.4 |
SMAD, mothers against DPP homolog 3 (Drosophila) |
| SMAD7 |
1857_at |
2.3 |
2.2 |
SMAD, mothers against DPP homolog 7 (Drosophila) |
| SOCS1 |
41592_at |
0.1 |
0.1 |
suppressor of cytokine signaling 1 |
| SPRY2 |
33700_at |
2.0 |
1.8 |
sprouty homolog 2 (Drosophila) |
| STK38L |
32182_at |
3.7 |
3.8 |
serine/threonine kinase 38 like |
| TGFBR3 |
1897_at |
0.3 |
0.5 |
transforming growth factor, beta receptor III (betaglycan) |
| TNFRSF1B |
1583_at |
0.4 |
0.6 |
tumor necrosis factor receptor superfamily, member 1B |
| TNFRSF1B |
33813_at |
0.4 |
0.4 |
tumor necrosis factor receptor superfamily, member 1B |
| TSPAN-2 |
35497_at |
4.2 |
5.0 |
tetraspan 2 |
| Extracellular matrix remodelling/Cytoskeletal |
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| COL4A1 |
39333_at |
2.2 |
2.0 |
collagen, type IV, alpha 1 |
| COMP |
40161_at |
2.7 |
5.3 |
cartilage oligomeric matrix protein |
| COMP |
40162_s_at |
5.0 |
18.9 |
cartilage oligomeric matrix protein |
| CTGF |
36638_at |
4.8 |
6.1 |
connective tissue growth factor |
| CYR61 |
38772_at |
4.4 |
3.5 |
cysteine-rich, angiogenic inducer, 61 |
| ELN |
31621_s_at |
4.9 |
3.7 |
elastin |
| ELN |
39098_at |
8.4 |
11.6 |
elastin |
| PLAUR |
189_s_at |
2.7 |
2.8 |
plasminogen activator, urokinase receptor |
| PLOD2 |
34795_at |
2.5 |
1.8 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| SERPINE1 |
38125_at |
3.7 |
4.0 |
serine (or cysteine) proteinase inhibitor, clade E, member 1 |
| SERPINE1 |
672_at |
6.0 |
5.5 |
serine (or cysteine) proteinase inhibitor, clade E, member 1 |
| TIMP3 |
1034_at |
2.0 |
1.5 |
tissue inhibitor of metalloproteinase 3 |
| TIMP3 |
1035_g_at |
2.4 |
1.6 |
tissue inhibitor of metalloproteinase 3 |
| TPM1 |
36790_at |
2.3 |
1.7 |
tropomyosin 1 (alpha) |
| TPM1 |
36791_g_at |
2.7 |
2.1 |
tropomyosin 1 (alpha) |
| TPM1 |
36792_at |
2.5 |
2.0 |
tropomyosin 1 (alpha) |
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Mean fold change in mRNA abundance in TGFβ treated/untreated control and fibrotic lung fibroblasts (LF), respectively. Fibrotic lung fibroblast ratios represent the average of idiopathic and scleroderma-associated pulmonary fibrosis lung fibroblasts. | ||||
Renzoni et al. Respiratory Research 2004 5:24 doi:10.1186/1465-9921-5-24 |
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