Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

doi:10.1186/1465-9921-5-24

Respiratory Research

Volume 5

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Renzoni EA
Abraham DJ
Howat S
Shi-Wen X
Sestini P
Bou-Gharios G
Wells AU
Veeraraghavan S
Nicholson AG
Denton CP
Leask A
Pearson JD
Black CM
Welsh KI
du Bois RM

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Renzoni EA
Abraham DJ
Howat S
Shi-Wen X
Sestini P
Bou-Gharios G
Wells AU
Veeraraghavan S
Nicholson AG
Denton CP
Leask A
Pearson JD
Black CM
Welsh KI
du Bois RM
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Research

Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts

Elisabetta A Renzoni¹ , David J Abraham² , Sarah Howat³ , Xu Shi-Wen² , Piersante Sestini⁴ , George Bou-Gharios⁵ , Athol U Wells¹ , Srihari Veeraraghavan¹ , Andrew G Nicholson⁶ , Christopher P Denton² , Andrew Leask² , Jeremy D Pearson³ , Carol M Black² , Kenneth I Welsh¹ and Roland M du Bois¹

¹Interstitial Lung Disease Unit, Royal Brompton Hospital, Imperial College of Science, Technology and Medicine, Emmanuel Kaye Building, 1B Manresa Road, SW3 6LR, London, UK

²Division of Academic Rheumatology, Royal Free Hospital, London, U.K

³Centre for Cardiovascular Biology and Medicine, Guy's, King's, and St. Thomas' School of Biomedical Sciences, King's College London, UK

⁴Division of Respiratory Diseases, University of Siena, Siena, Italy

⁵MRC Clinical Science Centre, Hammersmith Campus, Imperial College London, UK

⁶Dept of Pathology, Royal Brompton Hospital, London, UK

author email corresponding author email

Respiratory Research 2004, 5:24doi:10.1186/1465-9921-5-24


Published:	30 November 2004

Additional files

Additional File 1:

Complete list of genes regulated by a four hour treatment with TGFβ in control and fibrotic fibroblasts This data set contains all the genes up- or down-regulated by a four hour treatment with TGFβ (according to the criteria described in the methods) in control and fibrotic lung fibroblasts. Fibrotic lung fibroblast fold ratios are the average of the fold ratios for lung fibroblasts from idiopathic pulmonary fibrosis and pulmonary fibrosis associated with systemic sclerosis. Genes are sub-grouped into functional classes. Affymetrix probe set numbers, approved gene symbols, gene names and GenBank accession numbers are provided in the table.

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