Aspergillus antigen induced goblet cell hyperplasia in wild-type, Mcp-1-/- and Ccr2-/- mice. Representative PAS-stained lung sections from PBS-treated wild-type mice (A) showed minimal PAS-positive staining (similar findings from Mcp-1-/- and Ccr2-/- control mice are not shown). Aspergillus antigen-treated wild-type (B), Mcp-1-/- (C) and Ccr2-/- mice (D) showed magenta staining in epithelial cells, which represents mucus. Aspergillus antigen exposure and sample collection are described in methods. Magnification, 40× objective.
Koth et al. Respiratory Research 2004 5:12 doi:10.1186/1465-9921-5-12