|
Chromosomal regions showing evidence for linkage to asthma and related phenotypes |
|||
| Chromosomal region |
Phenotype (linkage) |
Population |
Reference |
|
|
|||
| 5q23-33 |
Total IgE |
Dutch, Amish, Caucasian (UK) |
[S8,S9,S10] |
| Total IgE, specific IgE, eosinophil count |
Australian |
[S11] |
|
| Specific IgE |
African American |
[S12]* |
|
| Atopic dermatitis |
Caucasian (UK), German/Swedish |
[S13,] |
|
| Asthma/atopy |
Japanese |
[S6,S15]* |
|
| Eosinophil count |
Caucasian (US) |
[S16] |
|
| Hypereosinophilia |
Caucasian (US) |
[S17] |
|
| Bronchial hyperresponsiveness |
Dutch, Hutterites |
[S3,S18]* |
|
| 6p21-23 |
Specific IgE |
Caucasian (US) |
[S1,S19] |
| Asthma, IgE |
German/Swedish |
[S5]* |
|
| Allergic asthma |
Colombian |
[S20] |
|
| Eosinophil count |
Caucasian (Australian) |
[S2]* |
|
| 11q13 |
IgE |
Caucasian (UK) |
[S21,S22] |
| IgE, positive skin test |
Caucasian (Australian) |
[S2]* |
|
| Specific IgE |
Caucasian (Australian), African American |
[S11,S12] |
|
| Bronchial hyperresponsiveness, log IgE |
Caucasian (UK) |
[S10] |
|
| Bronchial hyperresponsiveness |
Caucasian |
[S23] |
|
| Atopy |
Japanese |
[S24] |
|
| Asthma, atopy |
Caucasian |
[S25] |
|
| Atopic dermatitis |
German |
[S26] |
|
| 12q14-24 |
Asthma |
German/Swedish Caucasian (US) |
[38,S27]* |
| Caucasian (UK) |
[S28] |
||
| Asthma, atopy |
Afro-Caribbean |
[S29] |
|
| Total IgE, asthma |
Afro-Caribbean, Amish |
[S30] |
|
| Total IgE |
German |
[S31] |
|
| Bronchial hyperresponsiveness |
Hutterites |
[S3]* |
|
| Eosinophil count |
French |
[S7]* |
|
| 13q11-32 |
Atopic dermatitis |
German/Swedish |
[S14] |
| Specific IgE |
Caucasian (UK) |
[S1]* |
|
| Atopy |
Caucasian (Australian) |
[S2]* |
|
| Eosinophil count |
French |
[S7]* |
|
| Asthma |
Caucasian (US), Japanese |
[38*,S6*] |
|
| Atopic asthma |
Japanese |
[S32] |
|
|
*Genome-wide searches. | |||
Sengler et al. Respiratory Research 2002 3:7 doi:10.1186/rr179 |
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